news
Potential therapeutic target found for the Zika virus
A discovery about Zika’s enzyme, NS2B-NS3, offers promise for therapeutic targets for Zika and other flaviviruses.
List view / Grid view
Zika virus
news
Novel mRNA vaccines developed against Zika and HIV-1 viruses
US scientists have developed new mRNA vaccines for Zika virus and HIV-1 that produce a strong mother-to-child transmission of antibodies, in rabbits.
news
Novel Zika vaccine shows promise in animal models
A potential Zika virus vaccine, developed by deleting part of the Zika genome that codes for the viral shell, was effective and safe in mice.
article
mRNA vaccine technology – a promising platform for novel vaccine development
Dr Pushpanathan Muthuirulan explores why messenger RNA (mRNA) is advantageous for vaccine development and how the COVID-19 pandemic has accelerated its progress within the pharmaceutical industry.
article
Assessing compound activity to accelerate drug discovery
In this article, Drug Target Review’s Victoria Rees explores a new screening platform that assesses the biological activity of molecules to identify potential drugs. Using their new technique, researchers from the US National Institutes of Health (NIH) identified potential COVID-19 therapeutics.
news
GRP78 molecular chaperone revealed as drug target for COVID-19
Using computer modelling, a team has shown that a molecular chaperone called GRP78 could be targeted by drugs in strategies to treat COVID-19.
news
Brain organoids reveal mechanisms of virus-induced microcephaly
Researchers have shown how different viruses such as HSV-1 and Zika can lead to microcephaly using brain organoids.
news
Novel Zika virus vaccine shows success in pre-clinical trials
A new VLP-based Zika virus vaccine is able to protect mice completely from infection, researchers have found.
news
Mosquito protein could hold key to therapeutics against flaviviruses
A study has shown the mosquito protein AEG12 inhibits flaviviruses, the family of viruses that cause yellow fever, dengue and Zika.
article
What we know about COVID-19 and the inflammatory response
A year on from discovering COVID-19 we are starting to understand why some people suffer more severely after infection. Sadya Arnett discusses recent research into the interconnection between host inflammation and SARS-CoV-2.
news
Screening by compound activity could accelerate drug discovery
Researchers have developed a new screening technique called biological activity-based modelling to identify drug candidates.
news
Researchers identify how Zika infects foetuses and a potential drug to prevent it
According to scientists, maternal cells act as a reservoir for Zika, enabling the virus to pass from mother to foetus during pregnancy.
news
2B7 antibody could be the breakthrough needed for dengue fever therapies
Scientists show that an antibody targeting a protein acting as a viral toxin, can prevent the dengue virus from infecting human cells.
news
Tetracycline antibiotics show promise against Zika virus
A new study shows that methacycline, a commonly used antibiotic, can reduce the neurological damage caused by Zika virus infections in mice.
news
NIAID unveils new Centers for Research in Emerging Infectious Diseases (CREID)
The global network of centers will investigate where pathogens emerge and how they adapt to cause disease in humans, in the hopes of increasing our preparedness for future disease outbreaks.