Dr David P Siderovski (BellBrook Labs)

Unique self-activating proteins for drug discovery

5 January 2024 | By Bishal Parajuli (BellBrook Labs), Dr David P Siderovski (BellBrook Labs), Dr Dustin E Bosch (BellBrook Labs), Joseph Mendez (BellBrook Labs)

Naegleria fowleri infections are rare but almost invariably fatal, with pathologic sequelae spawning its common label as ‘the brain-eating amoeba’. Researchers identified two unique proteins within N. fowleri – self-activating guanine nucleotide-hydrolysing proteins (G proteins) – that present novel targets for drug discovery. This article summarises their work to date,…