Dr Matthew Lloyd (University of Bath)

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Assay performance and the Z’-factor in HTS

30 March 2023 | By Dr Matthew Lloyd (University of Bath)

Matthew Lloyd from the University of Bath reveals the importance of the Z-factor and Z’-factor in high-throughput screening, and how they can be used to determine assay performance, perform quality control on the screen, and identify active compounds.

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Why some screening hits are a PAIN

22 June 2021 | By Dr Matthew Lloyd (University of Bath)

A major challenge during high-throughput and fragment screening is the potential for identifying ‘frequent hitters’ – compounds that affect unrelated targets. Matthew Lloyd from the University of Bath explains why these hits can arise during drug discovery and how machine learning could be the answer to identifying these compounds.