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Chemokines work undercover as drivers of autoimmune disease
New research has uncovered a hitherto unknown mechanism whereby chemokines form DNA-bound nanoparticles that play a key role in autoimmune disorders.
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Mandy Parrett (Drug Target Review)
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Soft nickases could be the future of safe, effective gene editing
Researchers in the US have developed a new CRISPR method for treating genetic conditions using nickases that they say is safer and more effective.
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Blocking host proteins: an improved COVID-19 treatment approach?
Scientists report news of a promising new compound that effectively blocks the activity of proteins on cells that are necessary for SARS-CoV-2 to cause infection.
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New research sheds light on what influences target protein binding time
The length of time that drug molecules attach to their target protein varies greatly and impacts the protein’s behaviour and drug efficacy. In a new study, scientists in Finland have identified some causal factors for this variance, with the hope it will bring clarity for drug developers.
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Multifaceted flu vaccine demonstrates wider protection
Scientists at Georgia State University have developed an intranasal influenza vaccine using a new combination of nanoparticles for improved defence against flu strains.
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New model yields promising gene therapy for heart condition
Scientists in Japan have developed a credible heart cell model for arrhythmogenic cardiomyopathy and observed a positive response in the condition using PKP2 gene therapy.
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Important Omicron insights to aid treatment success
Knowledge is power – for scientists at least – and thanks to collaborative research from a UK and German university, we now have better understanding of the SARS-CoV-2 Omicron virus, including how it behaves and effective means of treatment.
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Understanding the tau tangles in neurodegeneration could aid treatment discovery
Representing a breakthrough in better understanding how tau proteins cause neurodegenerative disease, scientists have mapped the tau interactome.
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Successful liver model developed for research into UCD
Urea cycle disorders affect the liver’s ability to excrete urea from the body. To test potential therapeutics requires an accurate model – a hurdle that has now been successfully navigated thanks to a team of researchers in Switzerland.
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Opportune identification of novel multiple myeloma target
During investigations into the tropical disease Buruli ulcer, researchers have instead identified a promising new avenue for potential treatments for multiple myeloma.
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Ingenious AI method for improved target identification
A research team based at Skoltech in Russia has developed an artificial intelligence-driven solution for highly accurate detection of efficacious binding sites to expedite drug discovery.
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Novel method for chemo capture – up to three times more effective
A team of researchers in the US has devised a new means of removing excess chemotherapy drugs from a patient’s bloodstream, with potential for wider clinical and materials science applications.
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Collaborative research efforts enabled rapid response to Omicron variant
News from the Pasteur Institute in France reports on how multi organisational efforts of numerous research institutes enabled the scientific community to gain key insight into the Omicron variant, facilitating a rapid life-saving response.
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Scientists discover compound to combat multidrug-resistant bacteria
Taking a novel approach to antibiotic discovery, researchers at Rockefeller University have hit upon a promising solution to the problem of superbugs – a pervasive threat in hospitals the world over.
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Scientists develop means to boost the power of CRISPR
The capability to edit genes has been transformative in opening therapeutic avenues for hitherto untreatable diseases and aiding biological insight. Scientists have now discovered a way to enhance this process using retrons, making the process more efficient and effective.