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Cancer research

Overcoming obstacles in personalised medicine

11 December 2024 | By Drug Target Review

Tune in to this episode to learn how overcoming the key challenges in personalised medicine could transform the future of healthcare.

Cancer detection and screening as a treatment for malignant cells with a biopsy or testing caused by carcinogens and genetics with a cancerous cell.

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AI paves the way for new immunotherapy targets

11 December 2024 | By Michelle Teng - CEO of Etcembly

To fully unlock the potential of immunotherapy for cancer patients, we need better targets, not just better treatments. Hear from Michelle Teng, CEO of Etcembly, on how AI is decoding the immune repertoire and designing new therapies.

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FDA greenlights AI-developed drug targeting solid tumors

4 December 2024 | By Drug Target Review

Insilico Medicine’s AI-designed drug ISM5939 has received FDA IND clearance for treating solid tumours. By targeting ENPP1, it enhances anti-tumour immunity and is set to begin Phase I trials soon.

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New DNA nanostructures set to transform cancer treatment

3 December 2024 | By Drug Target Review

A University of Sydney study reveals how DNA origami can build programmable nanostructures, with promising applications in targeted drug delivery and nanorobotics.

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New CAR-T therapy shows promise in leukaemia treatment

1 December 2024 | By Drug Target Review

Obecabtagene autoleucel (obe-cel) has demonstrated strong efficacy in treating relapsed B-cell leukemia, with high response rates and minimal side effects.

Two scientists shaking hands in a laboratory setting

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USC partners with Autobahn Labs to accelerate drug discovery

26 November 2024 | By Drug Target Review

New collaboration focuses on transforming academic research into innovative therapies for urgent medical conditions, including cancer and heart disease.

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Biotech leader champions targeted cancer treatments and diversity

25 November 2024 | By Dr Catherine Pickering (iOnctura), Drug Target Review

Driven by a passion for innovation and inclusivity, Dr Catherine Pickering, CEO of iOnctura, is on a mission to transform cancer treatment while championing diversity within the biotech industry.

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INPP4B exerts its tumour-promoting effects via lysosomes

31 October 2024 | By Drug Target Review

Researchers have uncovered a how INPP4B, alongside PIKfyve and TRPML-1, drives pancreatic cancer metastasis.

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Computational pipeline for personalised cancer vaccine design

16 October 2024 | By

Ludwig Cancer Research researchers have designed and validated a computational pipeline which integrates molecular and genetic analyses.

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How chronic stress hastens the progression of colorectal cancer

14 October 2024 | By Drug Target Review

A new study, presented at the United European Gastroenterology, reveals how chronic stress disturbs the balance of gut microbiota and influences CRC progression.

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Developing the world’s first ovarian cancer prevention vaccine

7 October 2024 | By Drug Target Review

Cancer Research UK-funded researchers aim to identify targets for an ovarian cancer vaccine, which could prevent the disease at an early stage.

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KRAS variants in human pancreatic cancer: new key findings

4 October 2024 | By Drug Target Review

Researchers have identified underlying KRAS mutations which drive associated risk of particular clinical outcomes.

Imaging agent helps predict success of lung cancer therapy

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New combination treatment enables targeting of non-responsive lung tumours

26 September 2024 | By Drug Target Review

The newly identified KRAS G12C inhibitor, with SHP2 inhibition, sensitises tumours to immune checkpoint blockade.

Cancer,Outbreak,And,Treatment,For,Malignant,Cancer,Cells,In,A

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Looking beyond traditional oncogenic pathways to break cancer resistance

25 September 2024 | By Stefanie Flückiger-Mangual (TOLREMO Therapeutics)

Drug resistance is the leading cause of poor clinical outcomes for cancer patients undergoing targeted therapies. While current treatments are designed to inhibit targets along established oncogenic signalling cascades, a new, exciting approach is to address non-oncogene-related resistance mechanisms that operate in parallel to the “classic” oncogene pathways. Blocking transcriptional…

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Anti-PD-1 autoantibody: a biomarker candidate for HCC

24 September 2024 | By Drug Target Review

The researchers discovered that anti-PD-1 autoantibodies influence the outcome of Atezo/Bev therapy for hepatocellular carcinoma.

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Cancer research