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Cancer research

Breast cancer could be prevented by targeting epigenetic proteins

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The mechanism of PARP inhibitor action is identified

22 March 2024 | By Drug Target Review

New findings will enable the development of safer PARP inhibitors that inhibit PARP’s enzymatic activity without trapping it on DNA.

news

Exact bacterial lineage associated with colorectal cancer pinpointed

21 March 2024 | By Drug Target Review

Researchers have discovered two distinct lineages of Fusobacterium nucleatum, which has great implications for colorectal cancer screening and therapeutics.

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Potential for personalised, molecularly guided UTUC treatments

20 March 2024 | By Drug Target Review

The findings from DNA and RNA sequencing in primary and metastatic UTUC tumours could lead to strategies to improve patient outcomes.

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The advancement of drug-free immunotherapy

20 March 2024 | By Ellen Capon (Drug Target Review)

Researchers have created a neutrophil therapy, involving micropatches that maintain the cells’ antitumour state, which could offer significant clinical and commercial value.

article

Optimised antibody panels for CTC and rare cell enumeration

20 March 2024 | By Joby Chesnick (Bio-Rad), Tracey Long (Bio-Rad)

Despite significant strides in cancer research, metastasis remains the primary cause of cancer-related mortality globally. Joby Chesnick and Tracey Long, from the Digital Biology Group and Life Science Group, respectively, at BioRad Laboratories, reveal how investigation into circulating tumour cells (CTCs) and other rare cell types has led to the…

news

New link between FBXW7 mutations and EGFR signalling identified

19 March 2024 | By Drug Target Review

The Organoid Group have discovered a link between FBXW7 mutations and the EGFR signalling pathway, which could improve colorectal cancer treatments.

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Targeting cancer cells in early hypoxia

18 March 2024 | By Drug Target Review

Inhibiting the LDHA and GOT1 enzymes could prevent cancer cells’ ability to produce energy, without affecting healthy cells.

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Targeting Inc-HLX-2-7 shrinks group 3 medulloblastoma tumours

15 March 2024 | By Drug Target Review

An intravenous treatment to block lnc-HLX-2-7 from binding to the HLX promoter shrunk medulloblastoma tumours, prolonging survival in mice.

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P47 suppresses metastasis of HER2-positive breast cancer

12 March 2024 | By Drug Target Review

Results from an in vivo CRISPR knockout screen, targeting genes involved in autophagy, could lead to new therapies.

Chain of amino acid or bio molecules called protein - 3d illustration

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How fusion proteins drive paediatric cancer

8 March 2024 | By Drug Target Review

Researchers discover that fusion proteins and a gene regulatory protein complex interact through disordered domains.

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New algorithm identifies high-risk precancerous lesions

7 March 2024 | By Drug Target Review

Researchers have developed an algorithm which could improve diagnostics of ovarian high-grade serous carcinoma.

article

Breakthrough for pancreatic cancer treatment

7 March 2024 | By Ellen Capon (Drug Target Review)

Researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.

article

Scalable precision design targeting complex product profiles

6 March 2024 | By Dr Víctor Sebastián Pérez (Exscientia), Ellen Capon (Drug Target Review)

We had the privilege of speaking to Dr Víctor Sebastián Pérez, Associate Director of Computational Drug Design, following his presentation at ELRIG UK 2023. He shares his insights into how Exscientia is using AI to design drug candidates for cancer treatment.

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Potential new treatment options for KSHV-associated cancers

4 March 2024 | By Drug Target Review

Treatment with Palbociclib and a compound targeting CAD increased survival to 100 percent for selected lymphoma cell lines.

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Defining the senescence profile of colon fibroblasts

4 March 2024 | By Drug Target Review

Researchers have generated a SASP atlas of human colon fibroblasts and assessed the resulting transcriptome.

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Cancer research