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The IKAROS protein is crucial for B cell development
By mapping the genome, scientists have discovered how IKAROS enables differentiation of hematopoietic stem cells into B cells.
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Cell & gene therapy
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New technology optimises mesenchymal stem cell extraction
A continuous sorting technique of stem cells on a DLD microfluidic platform may greatly advance cell therapy.
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New contamination-detection test to improve T-cell therapy
Method to improve sterility assurance in biopharmaceutic manufacturing will lead to better patient outcomes.
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Noncoding RNA could be a new target for acute myeloid leukaemia
Discovery about the DNA of leukaemia cells suggests promising target for gene therapy in paediatric oncology.
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Genetically engineered transplants avoid immune rejection
Researchers have found a way to genetically modify stem cells so that cell and organ transplants are not rejected.
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Promising strategy for glaucoma cell replacement therapy
Changing blood stem cells into retinal ganglion cells that can migrate to the eye’s retina offers hope for cell replacement therapy.
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Macrophage phenotype insights could improve immunotherapy
A certain macrophage phenotype is more effective than another phenotype commonly used in cell therapy for infiltrating tumours.
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Handbook: Advanced flow cytometry handbook
Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.
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Rare genetic variant blocks common Alzheimer’s disease risk factor
New understanding of “Christchurch mutation” in the APOE gene may lead to novel Alzheimer's disease treatments.
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Understanding intracellular processes improves LYTACs therapy
New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.
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Potential new targets for chronic liver disease
Fatty liver disease treatments may become more effective after identification and greater understanding of more drug targets.
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Utilising CAAR T cells to treat antibody-caused brain disease
Researchers have engineered CAAR T cells to destroy harmful antibodies, improving NMDA receptor encephalitis treatment.
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Reduced motor symptoms of Parkinson’s disease
In rodent and nonhuman primate animals, circuit-specific gene therapy offers promise for Parkinson’s disease and other brain disorders.
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Machine could make CAR T-cell therapy more accessible
Researchers have developed a new bioreactor that can manufacture T cells faster than other technologies, which may advance immunotherapy.
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Key epitope can trigger tumour cell death
An epitope on CD95 receptor causes tumour cells to self-destruct and may prolong benefits of CAR T-cell therapy for solid tumours.