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Cell & gene therapy

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Macrophage phenotype insights could improve immunotherapy

17 November 2023 | By Drug Target Review

A certain macrophage phenotype is more effective than another phenotype commonly used in cell therapy for infiltrating tumours.

whitepaper

Handbook: Advanced flow cytometry handbook

15 November 2023 | By Sartorius

Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.

news

Rare genetic variant blocks common Alzheimer’s disease risk factor

14 November 2023 | By Drug Target Review

New understanding of “Christchurch mutation” in the APOE gene may lead to novel Alzheimer's disease treatments.

Assays for protein degradation therapeutics to accelerate undruggable proteome discoveries

article

Understanding intracellular processes improves LYTACs therapy

7 November 2023 | By Ellen Capon (Drug Target Review)

New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.

Obese man with fatty liver, 3D illustration. Conceptual image for non-alcoholic fatty liver disease

news

Potential new targets for chronic liver disease

6 November 2023 | By Drug Target Review

Fatty liver disease treatments may become more effective after identification and greater understanding of more drug targets.

news

Utilising CAAR T cells to treat antibody-caused brain disease

6 November 2023 | By Drug Target Review

Researchers have engineered CAAR T cells to destroy harmful antibodies, improving NMDA receptor encephalitis treatment.

news

Reduced motor symptoms of Parkinson’s disease

3 November 2023 | By Drug Target Review

In rodent and nonhuman primate animals, circuit-specific gene therapy offers promise for Parkinson’s disease and other brain disorders.

news

Machine could make CAR T-cell therapy more accessible

27 October 2023 | By Drug Target Review

Researchers have developed a new bioreactor that can manufacture T cells faster than other technologies, which may advance immunotherapy.

news

Key epitope can trigger tumour cell death

24 October 2023 | By Drug Target Review

An epitope on CD95 receptor causes tumour cells to self-destruct and may prolong benefits of CAR T-cell therapy for solid tumours.

news

Microcapsule-loading exosomes to treat vitreoretinal diseases

24 October 2023 | By Drug Target Review

Scientists have developed ExoCaps, self-healing microcapsules that are more feasible than other cell-based technologies.

news

SCID-X1 gene therapy successful with 3D genome architecture

16 October 2023 | By Drug Target Review

New research improves patient care by finding where gene copies integrate into DNA and using lentiviral vectors.

news

Human-derived proteins used in DREAM tool

16 October 2023 | By Drug Target Review

CRISPR-DREAM tool used to activate insufficiently expressed genes and convert skin cells to induced pluripotent stem cells (iPSCs).

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Cell & gene therapy