List view / Grid view

Hit-to-Lead

Black and red capsules in a pile with top one labelled 'COVID-19' in white writing - idea of a tablet/pill COVVID-19 vaccine

news

COVID-19 vaccine tablet significantly reduces viral load in hamsters

17 November 2020 | By Hannah Balfour (Drug Target Review)

Hamster challenge study results suggests the oral COVID-19 vaccine induces a robust immune response, protecting the animals from infection.

cancerous cell with crosshares over it - idea of targetted cancer therapy

news

LMTK3 inhibitors could be an effective breast cancer therapy, say scientists

16 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.

article

Developing nanobodies and sybodies to combat COVID-19

13 November 2020 | By Hannah Balfour (Drug Target Review)

Three separate studies have identified nanobodies – a miniature form of antibodies found in camelid species – that can bind to the SARS-CoV-2 Spike (S) protein and neutralise the virus in cells.

MRI of a glioblastoma in the brain of a patient (in frontal lobe near the right eye)

news

Novel nanoparticle therapy shows promise in glioblastoma

11 November 2020 | By Hannah Balfour (Drug Target Review)

The synthetic protein nanoparticle can cross the blood-brain barrier and deliver a targeted therapeutic to glioblastoma cells, say researchers.

Close up graphic of SARS-CoV-2 particle in grey, with red spike proteins, binding to a yellow cell surface ACE2 receptor

news

Researchers develop ACE2 decoy to neutralise SARS-CoV-2

10 November 2020 | By Hannah Balfour (Drug Target Review)

Using their de novo protein design strategy, researchers engineered human angiotensin converting enzyme 2 (hACE2) protein decoys that can protect cells from SARS-CoV-2 infection.

Three-dimensional (3D) illustration of amyloid beta plaques (brown mesh-like shapes) forming between neurons and disrupting their function. Amyloid plaques are a hallmark of Alzheimer’s Disease.

news

Developing drugs for disordered proteins

6 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.

red immune cell attacking a blue cancer cell on a dark blue background

news

Researchers develop novel class of cancer immunotherapy

30 October 2020 | By Hannah Balfour (Drug Target Review)

The scientists developed a therapy which uses nanobiologics to train the innate immune system to recognise and combat cancer cells.

whitepaper

ebook: Phenotypic screening with iPSC-derived cardiomyocytes and neurons

27 October 2020 | By Molecular Devices

Identify therapeutic effects and adverse responses to compounds earlier in the drug discovery process.

news

Novel anti-inflammatory slows progression of MS in mice

22 October 2020 | By Hannah Balfour (Drug Target Review)

When delivered intranasally, the anti-inflammatory drug VX-765 prevented axon demyelination and loss in a murine model of multiple sclerosis (MS).

glass vial labelled 'Alzheimer's Vaccine'

news

Novel Alzheimer’s vaccine shows promise in murine models

21 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists who developed the E22W42 DC vaccine suggest it could be safer and more effective than previous anti-amyloid Alzheimer’s therapies.

whitepaper

Webinar: High-content analysis and phenotypic characterisation of 2D and 3D cellular models

20 October 2020 | By Molecular Devices

Combining 2D and 3D models with live-cell assays allows monitoring of cell responses in real time and provides important insights about compound treatment effects, biological complexity, and physiological relevance of assay results.

RNA strands in orange on a blue background

news

Novel siRNA therapy improves psoriasis in mice

19 October 2020 | By Hannah Balfour (Drug Target Review)

Topical delivery of a small interfering RNA (siRNA) using an ionic liquid complex significantly reduced levels of inflammatory cytokines and symptoms of psoriasis.

whitepaper

Application note: Phenotypic characterisation of neuroactive compound effects

19 October 2020 | By Molecular Devices

Learn how to perform complex analysis of calcium oscillations and assess cellular and mitochondrial toxicity.

man holding the front of his head with the temporal lobe of the brain highlighted in red

news

D-serine could protect against epileptic seizures

15 October 2020 | By Hannah Balfour (Drug Target Review)

Scientist identified the mechanism through which temporal lobe epileptic seizures are sparked and that D-serine can interfere with this process, preventing seizures.

Wasp on a wooden platform [Credit: University of Pennsylvania].

news

Novel antimicrobial molecules derived from wasp venom

13 October 2020 | By Hannah Balfour (Drug Target Review)

Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.

Cookie	Type	Duration	Description
cookielawinfo-checkbox-advertising-targeting	persistent	1 year	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertising & Targeting".
cookielawinfo-checkbox-analytics	persistent	1 year	This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".
cookielawinfo-checkbox-necessary	persistent	1 year	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance	persistent	1 year	This cookie is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Performance".
PHPSESSID	session	1 year	This cookie is native to PHP applications. The cookie is used to store and identify a users' unique session ID for the purpose of managing user session on the website. The cookie is a session cookies and is deleted when all the browser windows are closed.
viewed_cookie_policy	persistent	1 year	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
zmember_logged	session	1 year	This session cookie is served by our membership/subscription system and controls whether you are able to see content which is only available to logged in users.

Cookie	Type	Duration	Description
advanced_ads_browser_width	persistent	1 month	This cookie is set by Advanced Ads and measures the browser width.
advanced_ads_page_impressions	persistent	2 years	This cookie is set by Advanced Ads and measures the number of previous page impressions.
advanced_ads_pro_server_info	persistent	1 month	This cookie is set by Advanced Ads and sets geo-location, user role and user capabilities. It is used by cache busting in Advanced Ads Pro when the appropriate visitor conditions are used.
advanced_ads_pro_visitor_referrer	persistent	1 year	This cookie is set by Advanced Ads and sets the referrer URL.
bscookie	persistent	2 years	This cookie is a browser ID cookie set by LinkedIn share Buttons and ad tags.
IDE	persistent	2 years	This cookie is set by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.
li_sugr	persistent	3 months	This cookie is set by LinkedIn and is used for tracking.
UserMatchHistory	persistent	1 month	This cookie is set by Linkedin and is used to track visitors on multiple websites, in order to present relevant advertisement based on the visitor's preferences.
VISITOR_INFO1_LIVE	persistent	5 months	This cookie is set by YouTube. Used to track the information of the embedded YouTube videos on a website.

Cookie	Type	Duration	Description
bcookie	persistent	2 years	This cookie is set by LinkedIn. The purpose of the cookie is to enable LinkedIn functionalities on the page.
GPS	persistent	30 minutes	This cookie is set by YouTube and registers a unique ID for tracking users based on their geographical location
lang	session	1 year	This cookie is set by LinkedIn and is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.
lidc	persistent	1 day	This cookie is set by LinkedIn and used for routing.
lissc	persistent	11 months	This cookie is set by LinkedIn share Buttons and ad tags.
vuid	persistent	2 years	We embed videos from our official Vimeo channel. When you press play, Vimeo will drop third party cookies to enable the video to play and to see how long a viewer has watched the video. This cookie does not track individuals.
wow.anonymousId	persistent	2 years	This cookie is set by Spotler and tracks an anonymous visitor ID.
wow.schedule	persistent	20 minutes	This cookie is set by Spotler and enables it to track the Load Balance Session Queue.
wow.session	persistent	20 minutes	This cookie is set by Spotler to track the Internet Information Services (IIS) session state.
wow.utmvalues	persistent	20 minutes	This cookie is set by Spotler and stores the UTM values for the session. UTM values are specific text strings that are appended to URLs that allow Communigator to track the URLs and the UTM values when they get clicked on.
_ga	persistent	2 years	This cookie is set by Google Analytics and is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. It stores information anonymously and assign a randomly generated number to identify unique visitors.
_gat	persistent	1 minute	This cookies is set by Google Universal Analytics to throttle the request rate to limit the collection of data on high traffic sites.
_gid	persistent	1 day	This cookie is set by Google Analytics and is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visited in an anonymous form.

Cookie	Type	Duration	Description
cf_ob_info	persistent	1 minute	This cookie is set by Cloudflare content delivery network and, in conjunction with the cookie 'cf_use_ob', is used to determine whether it should continue serving “Always Online” until the cookie expires.
cf_use_ob	persistent	1 minute	This cookie is set by Cloudflare content delivery network and is used to determine whether it should continue serving “Always Online” until the cookie expires.
free_subscription_only	session	1 year	This session cookie is served by our membership/subscription system and controls which types of content you are able to access.
ls_smartpush	persistent	1 month	This cookie is set by Litespeed Server and allows the server to store settings to help improve performance of the site.
one_signal_sdk_db	persistent	Until cleared	This cookie is set by OneSignal push notifications and is used for storing user preferences in connection with their notification permission status.
YSC	session	1 year	This cookie is set by Youtube and is used to track the views of embedded videos.

Recommended

Hit-to-Lead