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Video: Isolate Circulating tumor cells using the KingFisher
New opportunities for liquid biopsy: At automated workflow for isolating circulating tumor cells using KingFisher instruments.
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Hit-to-Lead
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ebook: How FBDD improves hit rates & delivers high-value targets
Learn how fragment-based drug discovery improves hit rates and delivers higher-value targets using various biophysical methods.
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High-throughput screening as a method for discovering new drugs
High-throughput screening is a common method of identifying lead compounds for drug development. The most common targets are enzymes – catalytic proteins that perform chemical reactions in the cell. In this article, Matthew Lloyd discusses the opportunities and challenges associated with this approach.
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Guide: Five ways biophysical tools help brain studies
Learn why researchers turned to biophysical methods to expose the molecular mechanisms of neurodegenerative diseases.
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Drug Target Review – Issue 2 2020
In this issue authors discuss the development of COVID-19 antibody therapies, how high-throughput screening enhances research at the Crick Institute and why combinations of immuno-oncology drugs could revolutionise treatment of advanced cancers. Also included in the issue are articles on stem cells and imaging.
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ebook: How to start your own lab
Learn practical tips from eight Principal Investigators about how to start your own lab.
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ebook: High-content analysis and infectious disease
Learn how you could use high-content analysis for functional & phenotypic assays in your infectious disease research or drug discovery.
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Multivalent carbohydrate-binding modules show efficacy against COVID-19
Tested on plaque reducing assays, researchers have identified a lead candidate multivalent carbohydrate-binding module for the treatment of COVID-19.
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Establishing Alpha CETSA HT in primary screening
7 May 2020 | By PerkinElmer
High-throughput screening (HTS) cascades have evolved to ensure that high quality hits can be identified from large screening collections.
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Three new assays to test COVID-19 antivirals developed
A series of three new assays to screen for drug compounds or proteins that combat the COVID-19 coronavirus has been developed.
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Developing respiratory therapeutics for prophylaxis and treatment
Drug Target Review explores antiviral Fc-conjugates and how they could be used as a COVID-19 prophylactic and therapeutic with Dr Jeff Stein, Cidara’s President and CEO.
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Researchers identify lead compounds for treatment of telomere diseases
Researchers investigating telomere dieases such as dyskeratosis congenita have found lead compounds that reverse cellular ageing in mouse models of the condition.
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Lead SARS-CoV-2 inhibitor compound identified by researchers to treat COVID-19
Researchers have found a lead compound which they say inhibits SARS-CoV-2 viral replication and demonstrates good pharmacokinetic activity in vivo.
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Screening 10,000 compounds identifies six potential COVID-19 therapeutics
High-throughput screening of thousands of compounds has revealed several candidates, including lead compound ebselen, with the potential for treating COVID-19.
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Celltrion selects 14 lead monoclonal antibodies for COVID-19 treatment
After screening 300 antibodies, Celltrion has identified the 14 most powerful that could potentially combat the COVID-19 coronavirus.
