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New link shown between innate immune sensing and cellular senescence
Scientists have discovered a cell intrinsic tumour suppressor role of the innate immune sensor Toll-like receptor 2.
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Study shows that immune cells determine growth of certain tumours
A new study shows that the growth rate of a tumour does not depend solely on how quickly the cancer cells can divide.
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Protein phosphorylation inhibition promotes optic nerve regeneration
New findings could be translated into the development of novel treatments for patients with optic neuropathies.
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In-depth research maps virulence factor of the influenza A virus in real time
Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.
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Novel findings could improve vaccinations against STIs
Researchers have shown how skin vaccinations could be used as a vaccination strategy for sexually transmitted infections (STIs).
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Researchers take a leap forward for new anti-inflammatory drugs
Treatments for chronic inflammatory diseases are one step closer as a new study discovers a way to stop inflammation in its tracks.
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New study finally explains the link between inflammation and gastric cancer
Researchers have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumours.
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Transforming drug discovery, development and delivery with flow chemistry
Flow chemistry is on the rise thanks to the commercial availability of benchtop continuous flow systems that has driven widespread adoption of the technique across a broad range of applications in both academia and industry. In particular, flow chemistry is delivering significant benefits in the area of drug discovery and…
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The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays
Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.
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Fast molecular interaction screening for all your projects
Current technologies that measure molecular interactions for drug discovery slow down and complicate screening. Dianthus is the answer to the demands for fast, non-stop, highly sensitive hit identification, hit validation and lead optimisation.
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Cell line development – global market drivers, trends and its impact on improving biologics development from early phase to IND during the drug discovery process
Cell line development is a major step for examining the efficiency of drug discovery, toxicity and in vitro testing. It reduces time, effort and cost, which minimises the chance of research drugs failing at the clinical trial stage. This stage involves the production of recombinant proteins such as monoclonal antibodies,…
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Ticagrelor reversal agent provides immediate and sustained relief
A reversal agent that sustains immediate relief from the side effects of ticagrelor stopping major bleeding, such as gastrointestinal hemorrhage...
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Drug Target Review – Issue 1 2019
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
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Potential EBV-associated cancer treatment in small molecule inhibitors
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
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Custom-made proteins create antibodies to fight HIV
Computational modelling has been used to design proteins that mimic the conserved protein surface of different strains of HIV for use in vaccines...