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Atg2 tethers pre-autophagosomal membranes to endoplasmic reticulum
Researchers at Tokyo University have investigated the role of the Atg2 protein in the process of autophagy to aid drug discovery into neurodegeneration...
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Novel DNA vaccine offers broad protection against Influenza-A H3N
Researchers developed a novel DNA influenza vaccine based on four micro-consensus antigenic regions selected to represent the diversity of seasonal H3N2 viruses...
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Rutin could be effective in treating snakebites from pit vipers
The action of a venomous snakebite from vipers could be treated using a flavonoid called rutin, an inexpensive plant based compound...
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SERDs molecules could spur a new class of drugs for breast cancer
Stevens researchers design and develop a new class of molecules for breast cancer therapy...
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PSD-95 molecule reveal potential treatment for stroke patients
A novel hybrid approach has revealed a 3D structure of a protein fragment that could serve as a drug target in treating stroke patients...
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Sugar specific molecules show promising results for new allergy vaccine
Using sugar molecules researchers have developed a new vaccine for hay fever that may reduce treatment times and increase the effectiveness of treatments...
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CT45 biomarker found in ovarian cancer can predict response to therapy
New approach could prolong survival and trigger an immune...
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Nanotherapy offers hope in treating drug-resistant renal cell carcinoma
A research team has developed a nano-platform technology that works in combination with existing chemotherapeutic drugs that may reverse drug-resistance in renal cell carcinoma...
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Cancer cells hide to evade immunotherapy
Cancer cells have been found to evade immunotherapy by hiding behind human leukocyte antigens, with researchers identifying therapies to prevent relapse...
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PD-1 and CTLA4 therapies together could benefit women with ovarian cancer
Women with ovarian cancer could in future benefit from a combined therapy using PD-1 and CTLA-4 as shown through the results of this Phase II trial...
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Green tea compound helps siRNA slip inside cells
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
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Six compounds identified from 70,000 to help eradicate malaria
Researchers from Imperial College London have identified 6 compounds from almost 70,000 that could help to eradicate malaria...
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Synthetic biology in drug discovery
Synthetic biology is broadly defined as the design and construction of novel artificial biological pathways, organisms or devices; or the redesign of existing natural biological systems.1 It brings together a range of disciplines and skills, from biology and chemistry to computing, bioinformatics and engineering.
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Neutralising antibodies could lead to HIV vaccine
Developing an HIV vaccine focuses on discovering the factors responsible for the production of antibodies that neutralise almost all known virus strains...
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The rise of high-throughput flow cytometry in drug discovery
Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Typically, cells are labelled with fluorescent markers and passed through a series of lasers, after which the resultant fluorescent…
