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Assays In-Depth Focus 2018
This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.
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Expert view: Managing the complexity of finding new targets and drugging the undruggable
Assessing targets that are unable – or rather, extremely difficult – to reach pharmacologically, has prevented researchers from achieving desired clinical successes, most notably in the realm of cancer research. However, many advances are being made to shedlight on these difficult yet desirable target areas.
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Applications of high content screening in autophagy
Autophagy is an important process to maintain cellular homeostasis and function.1 Basal levels of autophagy are essential for most cells to remove unwanted protein aggregates and damaged organelles in order to prevent diseases.2 However, sometimes cells are unable to maintain physiological stability as a consequence of altered autophagy, which leads…
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Neutrophil nanosponges soak up rheumatoid arthritis promoting proteins
The neutrophil nanosponges can absorb and neutralise cytokines which play a role in the development of rheumatoid arthritis...
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Drug Target Review – Issue 3 2018
In this issue: pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease, the evolving role of three dimensional in-vitro cell culture techniques in drug discovery, and NGS: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of genetic diseases.
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Cannabidiol shows sustained effects against depression
Researchers have found that a single dose of cannabidiol in rats with symptoms of depression was highly effective at eliminating symptoms...
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The changing face in drug discovery
Over the past decade, pharmaceutical industries have contributed enormously to the discovery of new innovative drugs that have saved countless human lives. Discovering new drugs is a complex team sport that requires an intellectual collaboration across many sectors. These advancements provide powerful tools that arm scientists in the quest for…
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Venoms could be used to treat cancer and autoimmune diseases
Venoms are continually being researched as potential chemicals for medicinal therapeutics to treat autoimmune diseases and diabetes...
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Scientists discover compound for a non-addictive painkiller
Scientists have discovered the chemical compound AT-121, which could soon lead to a painkiller stronger than morphine, but without the side effects...
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Potential drug to cure ciliopathies
Researchers have identified a potential treatment that will be a foundation for developing drugs for various genetic disorders...
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Experimental drug targets cancers associated with Epstein-Barr virus
An experimental drug is reported to have potential to treat Epstein-Barr virus related lymphomas by counteracting the cancer-promoting mechanisms of LMP2A...
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Modified-RNA vaccine elicits protective response against influenza
A universal flu vaccine that protects people against most influenza strains is one step closer to reality...
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Researchers develop biosensor with real-time oxygen monitoring
In a study, researchers have developed a biosensor concept using organs-on-a-chip to measure the levels of oxygen in real-time...
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Vitamin B3 could potentially treat kidney injury
A team of researchers have identified vitamin B3 can increase levels of NAD+, which is decreased in those with acute kidney injury...
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Compound with selectivity for cancer cells without p53 identified
The compound has been shown to target cancer cells without the p53 gene, and does not affect healthy cells...
