news
DNA-based Zika vaccine found effective at inducing immune response
A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...
List view / Grid view
Hit-to-Lead
news
NRF2 pathway provides new approach to cancer drug discovery
Scientists have developed a promising new strategy for the discovery of novel anti-cancer therapies for non-small-cell lung cancers...
news
Scientists develop broad-spectrum inhibitors of influenza virus
Scientists have developed broad-spectrum inhibitors of the influenza virus using artificial peptide molecules...
news
Novartis and UC Berkeley collaborate to tackle ‘undruggable’ disease targets
Collaboration aims to unlock difficult drug targets and accelerate the discovery of new medicines in areas such as infectious diseases and cancer...
news
CYC065-eribulin combination therapy for triple-negative breast cancer identified
Researchers find novel combination disrupts multiple factors in aggressive breast cancer...
news
Potential therapeutic protein inhibitors for Chagas disease
Researchers have used a multi-modal integrated approach to develop potential new anti-Chagas therapies...
news
Bryostatin-1 shows early promise for dormant HIV infection
Scientists have designed a synthetic molecule bryostatin-1 that can reactivate dormant HIV...
news
A fat-regulating enzyme could hold the key to diabetes and cancer
Researchers shed light on a key fat-regulating enzyme's role in diabetes and cancer...
article
Structure based drug discovery facilitated by crystallography
Drugs exert therapeutically meaningful effects if they bind with appropriate selectively and potency to their respective targets. Although many of the assay techniques employed in early-stage drug discovery provide evidence that a drug is acting upon the target under investigation, this is often indirect and the site of action and…
news
Antibiotic identified that reduces infection risk in young leukaemia patients
Researchers have identified an antibiotic that significantly reduced the odds of infections in children starting treatment for ALL without an apparent increase in antibiotic resistance...
news
Magnetic cellular ‘Legos’ for the regenerative medicine of the future
By incorporating magnetic nanoparticles in cells researchers have succeeded in creating cellular magnetic "Legos."...
news
Venomous compounds may lead to better skin treatments
Compounds derived from fire ant venom can reduce skin thickening and inflammation in psoriasis...
news
DNA sequencing could open up new drug indications for rare cancers
A network of hospitals have systematically collected biopsies from metastatic cancer patients in order to create a global database...
news
How receptors for medicines work inside cells
G protein-coupled receptors are the key target of a large number of drugs, scientists have now been able to show more precisely how these receptors act in the cell interior...
article
Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...
