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Drug Target Review – Issue #2 2015
10 June 2015 | By Drug Target Review
Included in this issue: Drug Discovery, Screening, Hit-to-Lead, Antibodies, Stem Cells, Kinases and much more...
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Hit-to-Lead
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Stem Cells In-Depth Focus 2015
10 June 2015 | By Kenji Schorpp, Kamyar Hadian, Sheraz Gul, Horst Flotow
This Stem Cells In-Depth Focus features articles on stem cell-derived cardiomyocytes, and their use in drug discovery and development, as well as a look at how venom could be used in stem cell differentiation...
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Screening In-Depth Focus 2015
10 June 2015 | By Kenji Schorpp, Kamyar Hadian, Sheraz Gul, Horst Flotow
In this Screening In-Depth Focus, high throughput screening is the topic focused on by Kenji Schorpp and Kamyar Hadian, Institute of Molecular Toxicology and Pharmacology, and Sheraz Gul, Fraunhofer Institute for Molecular Biology and Applied Ecology. They discuss the importance of the technique in drug discovery today as well as…
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Academic drug discovery in neurodegeneration; a new approach to an ageing problem
Dementia is a global crisis with 76 million people worldwide expected to be living with the condition by 2030. Current symptomatic treatments provide modest improvements in cognition but disease-modifying therapies for diseases like Alzheimer’s – the most common cause of dementia – do not yet exist.
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True screening for immunology: transforming science with a practical tool for large-scale discovery
10 June 2015 | By IntelliCyt Corporation
The immune system plays a vital role in keeping us alive but also participates in many diseases adversely affecting quality of life across the globe. It can be over activated, leading to a variety of inflammation and autoimmune diseases, or suppressed, leading to a vast array of diseases from AIDS…
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A new dawn in academic and pharma collaboration – a UK perspective
Academia and pharma have always been uneasy bedfellows. There has in the past been tension between both caused by a range of issues that neither party was willing to try and resolve. However, there is a new impetus to solve these issues as both parties have started to realise that…
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From hype to hope: challenging the norm in lead discovery
From the beginning of time in the drug discovery world, the integration of disciplines has driven the identification of new lead molecules. Chemists, pharmacologists and biologists work together to understand a disease state and how to perturb that state back towards a normal healthy condition. However, in the early days…
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Developing antibody therapeutics
Monoclonal antibodies have come of age as therapeutics; there are now more than 30 antibodies on the market and over 200 in clinical trials. The attractions of therapeutic antibodies lie not only in their potential to make potent drugs but also their relative low risk in comparison to small molecule…
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Researchers discover how C. difficile toxins enter the interiors of cells
9 June 2015 | By Victoria White
Researchers have identified the molecular docking site that is responsible for C. difficile toxins being able to bind to a receptor...
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Protein from Vibrio vulnificus can inhibit tumour cell growth by cutting the protein Ras
9 June 2015 | By Victoria White
Scientists have discovered that a toxin secreted by Vibrio vulnificus has potential to prevent the growth of tumours by cutting the protein Ras...
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Myxoma virus kills cancer cells while blocking graft-versus-host disease in bone marrow transplants
8 June 2015 | By Victoria White
Researchers have discovered that the myxoma virus can kill some kinds of cancer cells while eliminating a complication of bone marrow transplants...
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Organ-on-a-Chip and 3D-Printing in the Life Sciences Conference, Boston, July 8-9, 2015 features international roster of speakers.
8 June 2015 | By Select Biosciences
Select Biosciences is delighted to announce that its Organ-on-a-Chip and 3D-Printing in the Life Sciences Conference, Boston, July 8-9, 2015 features all the international key opinion leaders in the organ-on-a-chip/body-on-a-chip field as well as 3D-bioprinting fields...
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Drug abuse triggers regulations to push the development of abuse-free opioid formulations
8 June 2015 | By Victoria White
A $10 billion market exists for a company able to develop a novel, targeted opioid therapy that excludes side effects such as addiction and constipation...
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T cell exhaustion study has possible implications for cancer and antiviral therapies
4 June 2015 | By Victoria White
When the T cells of your immune system are forced to deal over time with cancer or a chronic infection, they can develop "T cell exhaustion"...
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Triple treatment keeps lung cancer from coming back
4 June 2015 | By Victoria White
Lung cancer often returns and the recurring cancer is often resistant to the chemotherapy and other drugs that originally drove it into remission...
