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New imaging technique developed to study fungi
German researchers have developed a novel imaging technique called expansion microscopy (ExM) to investigate fungi samples.
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Video: Increased reproducibility with KingFisher™ instruments
ESHG 2019 Conference Presentation: Using KingFisher™ to increase reproducibility in new applications using challenging samples.
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Nanoparticles used to kill endometriosis lesions in animal models
Using dye-loaded nanoparticles which can heat up with near-infrared light, researchers have been able to image and treat endometriosis in animal models.
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Novel tuberculosis transport protein could be target of new treatments
Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.
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Scientists reveal structure of norovirus using cryo-EM
Researchers captured 13,000 images of a mouse norovirus using an electron microscope and compiled the images to reveal the structure of the virus.
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ebook: Habitat for disease – disrupting the tumour micro-environment
No tumour prevails on its own. Rather, every tumour needs a community to thrive.
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Imaging technique allows study of early stage Alzheimer’s disease
Scientists used optical photothermal spectroscopy (O-PTIR) to image murine neurons affected by early stage Alzheimer’s disease, providing insight into the progression of the disease.
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New mass spec technique used to determine structure of sugars
A new method has been invented that boosts the mapping of heparan sulfates and which the researchers say could be widely used for drug discovery.
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COVID-19 research hub: promoting scientific collaboration
Drug Target Review has created a COVID-19 research hub with forum space for discussions and a place to share your research - plus all of our articles and news.
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Scientists propose new precise method to measure atoms
A team of Russian scientists has suggested a new method to measure the sizes of atoms as well as their intermolecular interactions, which they say could help drug design.
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High-speed microscope can capture brain signals and calcium concentrations
The novel technology allows researchers to create three-dimensional images of signal propagation and calcium concentration changes in the neocortex of live mice.
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Drug Target Review – Issue 1 2020
This issue includes a spotlight on how genomic assays could revolutionise healthcare, a discussion on how lab automation can improve drug discovery and an analysis of whether antibodies can provide an effective coronavirus treatment. Other article topics in this issue include immuno-oncology and artificial intelligence.
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Preliminary SARS-CoV-2 protease inhibitor shows efficacy in mice
Using X-ray crystallography, researchers have revealed the structure of the SARS-CoV-2 main protease, designing an inhibitor to bind to this target and prevent viral replication.
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Autonomous Scanning Probe Microscopy technique developed using AI
Using AI and deep learning, researchers have enhanced Scanning Probe Microscopy (SPM) and made their automated resource available for scientists.
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Where could bioengineering and technological advances take drug discovery?
Drug Target Review explores the findings of a recent review of molecular, cellular, multi-cellular and tissue engineering and modelling technologies for drug design.