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Study discovers key process in the cause of cell aging
Researchers have identified a key process behind senescence, or why cells age, which could be used to improve treatments for cancer.
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Imaging
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CRISPR-Cas9 gene editing imaged for first time
Researchers have generated images of CRISPR-Cas9 gene editing for the first time, enabling improvement of the technique.
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Discovering new routes to cancer drug discovery with neutrons
From the world’s flagship neutron science facility, Institut Laue-Langevin (ILL), Matthew Blakeley shares insights into how they are harnessing the power of neutrons to aid their search for new cancer treatments.
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Behaviour of mouse’s brain controlled with single-cell precision
Researchers prove it's possible to control a visual behaviour of a mouse by activating neurons in its visual cortex.
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New medicinal advances could be yielded by studying proteins in glass
A unique method for studying proteins has been developed which could open new doors for medicinal research.
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New method for developing medical imaging tracers discovered
A new medical imaging tracing method has been discovered by scientists which can better track drugs in the body.
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Norovirus structure imaged, providing potential for vaccine development
Researchers have been able to image noroviruses, providing significant information for the development of therapeutics.
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High-content imaging: challenges of the 3D world
The potential of three-dimensional cell culture models is now well-recognised by scientists; however, there are still some challenges. Margaritha Mysior and Jeremy Simpson address some of the common challenges of working with spheroids and organoid models – including how they are developed and how to obtain high-resolution, high-content images and…
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Image-based characterisation of cancer biotherapeutics
Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to progress drug discovery campaigns and identify the most promising candidates for antibody-based therapies.
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Expert view: High-content screening of complex physiologically-relevant cell models
High-content screening (HCS) approaches have become increasingly common in drug discovery with HCS technologies integrated across the drug discovery pipeline. Here we discuss recent developments in this arena.
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Imaging In-Depth Focus 2019
In this in-depth focus, the challenges of imaging are explored including how to develop high-resolution images. Also discussed are new imaging technologies to aid drug discovery.
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Phenotypic profiling in drug discovery
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
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Drug Target Review – Issue 2 2019
In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies and utilisation of stem cells to study the effects of cannabis on neuronal development.
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Study identifies novel lupus drug target
Structure of internal regulator molecule identified, presenting lupus drug potential.
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New method could speed up drug development and diminish drug trial fails
A new method of assessing the actions of medicines by matching them to their unique protein receptors could accelerate drug development.
