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Researchers plan to image every cell in the human brain at unprecedented speed
Columbia-led team wins research grant to create fundamentally new maps that will chart cell diversity throughout the brains of humans.
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Bulletin: Utilising the multiparameter capability of the Ze5 Cell Analyser to monitor T cell exhaustion and effects of immunotherapy
Read this bulletin to learn about a Bio-Rad study where they developed and tested a 16-parameter flow cytometry panel applicable to the interrogation of a range of biologically relevant markers of T cell activation.
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Enhancing confocal microscopy with AI
Improving processes in the lab can enable researchers to spend their time on other tasks and increase the accuracy of their findings, including when imaging. In this Q&A, Dr Hari Shroff from the US National Institutes of Health (NIH) discusses his recent study, published in Nature where confocal microscopy was…
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Drug Target Review – Issue 1 2022
In this issue are articles on the development of mRNA vaccines against latent viruses, how memory B cell antibody-based treatments can help to fight cancer and the potential of AI in drug discovery. Also included are pieces on biotherapeutics, immuno-oncology and assays.
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Clearer imaging approach captures images of blood vessels
Researchers have developed a new imaging approach that can capture blood vessel images at different spatial scales.
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Open-source framework developed for automated pipetting and imaging
Scientists have demonstrated how automated, high-throughput life science experiments can be replicated on a modest budget.
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Breakthrough method developed to grow model organs
Researchers have successfully generated organoids in suspension, offering the possibility of larger-scale experiments to study human development and disease.
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Image-based, quantitative approaches to study SARS-CoV-2 cell entry and infection: looking for the Achilles’ heel of virus infection
21 February 2022 | By Yokogawa Deutschland GmbH
Watch our free on-demand webinar to discover how fully automated imaging and image analysis can provide the unprecedented possibility to follow single viral particles, including for SARS-CoV-2.
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New cryo-EM method reveals insight into blood disorders
A molecular cage, developed for use during cryo-EM, has provided researchers with new insights into a key cancer protein.
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New research sheds light on what influences target protein binding time
The length of time that drug molecules attach to their target protein varies greatly and impacts the protein’s behaviour and drug efficacy. In a new study, scientists in Finland have identified some causal factors for this variance, with the hope it will bring clarity for drug developers.
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Scientists unveil first molecular-level analysis of Omicron spike protein
Using cryo-electron microscopy, researchers have completed the world’s first molecular analysis of the SARS-CoV-2 Omicron spike protein.
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Model insight into blood enzyme Lp-PLA2 could aid cardiovascular health
A new study in the US has used a computer model to reveal the mechanism of action of lipoprotein-associated phospholipase A2 – a biomarker for cardiovascular disease.
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T-cell immunotherapies and flow cytometry
Dr Alasdair Gunn and Natalie Bath from Adaptimmune explain how flow cytometry provides a useful tool for the development of immuno-oncology therapies. They also explore how they use this method for translational research of the company’s SPEAR T-cell products.
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Flow cytometry in drug discovery and development
With a range of tools available to scientists in the field of therapeutic discovery and development, flow cytometry presents an advantageous method to sort cells based on subtle differences. To find out more, Drug Target Review’s Victoria Rees spoke with Dr Peter O’Toole, Head of Imaging and Cytometry and Dr…
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Product hub: High-content 3D confocal imaging of live cell clusters
Learn about the high-content analysis system that provides high-quality three-dimensional imaging for enhanced live cell analysis.
