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Short peptides discovery could lead to new treatments for Alzheimer’s
The memory of mice with Alzheimer's greatly improved after they were injected with two newly discovered short peptides.
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Informatics
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Spotlighting data in upstream bioprocesses – a recipe for quick and successful cell lines
Upstream bioprocessing is the epicentre of biologics development, wherein scientists piece together a series of carefully chosen processes with contributing components and parameters to enable the production of highly effective biotherapeutics. Unjulie Bhanot explains why an effective data management system is vital in this quest for the next big therapeutic.
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Designing proteins from scratch with computer science
Marc Baiget-Francesch highlights interesting developments in the field of protein drug design and explains how continual software improvements are speeding up the process.
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Integrating drug discovery R&D
Pharmaceutical companies are under increasing pressure to get novel drugs to market as quickly as possible. Here, Sheraz Gul discusses how integrating processes could help streamline drug discovery in the future.
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Getting connected – the key to solving the reproducibility problem?
As technology advances and scientific research progresses at a rapid pace, data is being generated in ever-larger quantities. Even with the forward strides in technology and advances in data processing, a common problem widely acknowledged by the scientific community is that of reproducibility. In this article, Matjaz Hren discusses the…
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Whitepaper: Evaluating the impact of error rate on productivity and cost savings in synthetic DNA fragments
GeneArt High-Q Strings DNA Fragments versus other suppliers’ products.
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Largest genome sequencing project launched in UK
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
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Schizophrenia gene regulator identified by study
Using both computational models and stem cell-based experiments, researchers have identified a gene regulator of schizophrenia.
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Drug Target Review – Issue 3 2019
This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing.
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Medical Research Council updates brain tissue database
The UK Brain Banks Network has been enhanced to include genomic data, which can be accessed by researchers worldwide.
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AI learns chemistry language to predict how to make medicines
An algorithm has been developed which can predict the outcomes of complex chemical reactions with over 90 percent accuracy which can be applied to drug development.
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Human digestive tract database available for researchers
A team from MIT sequenced bacteria samples from the digestive system which can be accessed by researchers to use in the development of treatments.
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Pancreas-on-a-chip technology to aid in diabetes research
Scientists combine organ-on-a-chip and stem-cell technologies to make a powerful tool for diabetes research.
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AI designed, synthesised and validated new drug in 46 days
Researchers have developed a new AI system which was able to discover and then successfully test several new compounds within 46 days.
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New treatments for liver disease could be identified with lab-on-a-chip
New lab on a chip technology has been developed to evaluate the effects of different drivers of NAFLD on liver cells.