Informatics

Application note: Production of human induced pluripotent stem cell-derived cortical neurospheres in the DASbox^® Mini Bioreactor System

29 November 2018 | By Eppendorf

There is substantial interest in the scientific community in using human induced pluripotent stem cell (hiPSC)-derived neural cells to study basic mechanisms of brain development, neuronal function, and drug-induced effects. In vitro-generated brain organoids are promising models, because they show a remarkable degree of maturation and can be kept in…

Application note: Sensitive fluorometric quantification of DNA in microplate format

29 November 2018 | By Thermo Fisher Scientfic

This technical note demonstrates the feasibility of using the Thermo Scientific™Fluoroskan™ or Fluoroskan FL instruments with the Invitrogen™ Quant-iT™ dsDNAhigh-sensitivity assays. Sensitive and specific quantification of double-stranded DNA is carried out in microplate format. This is part of a series of technical notes aiming to help customers choose the best…

Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software

29 November 2018 | By Thermo Fisher Scientfic

Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.

Application note: Transforming your bioanalysis operations – is a lack of insight slowing you down?

29 November 2018 | By IDBS

Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.

Drug Target Review – Issue 4 2018

26 November 2018 | By Drug Target Review

In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.

High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland

9 November 2018 | By Beckman Coulter

In this webinar you learn about a high throughput screening approach for mining of antibody repertoires in the context of biologics drug discovery.

P2K system could resolve bottlenecks in drug research

7 November 2018 | By Drug Target Review

Researchers have developed a new system that could significantly speed up the discovery of new drugs and reduce the need for costly and time-consuming laboratory tests...

Harmonising drug-target binding data analytics on a single platform

6 November 2018 | By PerkinElmer

This webinar outlined the fundamentals of a design process where an experimental analytics data workflow is being integrated into a more seamlessly interactive platform...

Charles River and Distributed Bio enter exclusive partnership to create an integrated antibody discovery and development platform

5 November 2018 | By Charles River Laboratories

Charles River Laboratories International, Inc. announced that it has entered into an exclusive partnership with Distributed Bio, Inc., a leader in the computational design and optimisation of antibody discovery platforms...

AI algorithm accurately predicts Alzheimer’s disease onset

5 October 2018 | By Drug Target Review

Scientists have developed an algorithm that can more accurately predict cognitive decline that leads to Alzheimer’s disease. Early preventive measures may help delay and even halt the disease’s onset.

Expert view: Creating metabolic liabilities to target cancer

25 September 2018 | By Brian Dranka (Head of Biology and Application Development at Agilent Technologies)

As the pace of genetic approaches to combating cancer slows, researchers are focusing on novel approaches to identify and create metabolic liabilities in cells. Cancer cells rewire their metabolism to survive and proliferate rapidly; however, there is no single metabolic phenotype that enables this rewired state.

Agilent Technologies

A universal flu vaccine may be in sight

21 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers from Oxford have identified the initial steps on the path towards creating a universal influenza vaccine that could last for life...

ELRIG UK Drug Discovery 2018 Event

19 September 2018 | By ELRIG

ELRIG’s (European Laboratory Research & Innovation Group) Drug Discovery meeting, will take place at ExCeL, London, UK, located in the heart of the city, from 9 -10 October 2018...

Timing could be crucial when taking medication

14 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers used a bioinformatic tool to suggest that circadian timing could be key to the success of certain drugs or therapies...