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Informatics

Network-driven drug discovery

14 March 2019 | By Alan Whitmore - e-therapeutics Plc, Jonny Wray - e-therapeutics Plc

Target-driven drug discovery, in which the starting point is a specific protein target hypothesised to play an important role in disease, has been the dominant paradigm for the last few decades. However, phenotypic-driven drug discovery, which does not rely on a specific target hypothesis, is starting to regain traction for…

news

Machine-learning model to analyse protein sequences

14 March 2019 | By Iqra Farooq (Drug Target Review)

A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...

news

Using the SVM method to predict enhancers from tissues and cell lines

14 January 2019 | By Iqra Farooq (Drug Target Review)

A team of researchers have developed a computational bioinformatic method to predict and accurately locate enhancer regions on cell lines.

whitepaper

Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models

10 January 2019 | By Taconic Biosciences

Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.

news

AI used to diagnose diabetic eye disease

8 January 2019 | By Iqra Farooq (Drug Target Review)

Artificial Intelligence has been used to cost-effectively diagnose diabetic-related eye disease automatically with far more accuracy than current methods...

whitepaper

Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice

7 January 2019 | By Taconic Biosciences

Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.

news

Using machine learning to predict symptoms

2 January 2019 | By Iqra Farooq (Drug Target Review)

Machine learning could, in future, be the way that clinicians decide on particular courses of treatments for patients affected by cancer...

news

Oral squamous cell carcinoma prognostic signature identified

6 December 2018 | By Drug Target Review

Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...

article

Application Notes supplement 2018

4 December 2018 | By Drug Target Review

Researchers are always looking more effective and efficient ways of making their work more successful. In this supplement, some of our commercial partners share their data, detailing the application of their technology.

Stefan Duhr, CEO, NanoTemper Technologies

article

Expert view: Tackling drug discovery inefficiencies requires diverse libraries, technologies with broader applicability and actionable insights

4 December 2018 | By Stefan Duhr (CEO at NanoTemperTechnologies)

Inefficiencies in drug discovery are hard to ignore when despite ever-increasing investment in pharmaceutical research and development, the number of new drugs approved by the US Food and Drug Administration (FDA) remains low.

news

Digital 3D brain cell atlas released

30 November 2018 | By Fraser Owen (Drug Target Review)

The Blue Brain 3D atlas could be the future of analysing all cells in the brain, with high quality, high resolution images that can navigate the brain...

whitepaper

Application note: Production of human induced pluripotent stem cell-derived cortical neurospheres in the DASbox^® Mini Bioreactor System

29 November 2018 | By Eppendorf

There is substantial interest in the scientific community in using human induced pluripotent stem cell (hiPSC)-derived neural cells to study basic mechanisms of brain development, neuronal function, and drug-induced effects. In vitro-generated brain organoids are promising models, because they show a remarkable degree of maturation and can be kept in…

whitepaper

Application note: Sensitive fluorometric quantification of DNA in microplate format

29 November 2018 | By Thermo Fisher Scientfic

This technical note demonstrates the feasibility of using the Thermo Scientific™Fluoroskan™ or Fluoroskan FL instruments with the Invitrogen™ Quant-iT™ dsDNAhigh-sensitivity assays. Sensitive and specific quantification of double-stranded DNA is carried out in microplate format. This is part of a series of technical notes aiming to help customers choose the best…

whitepaper

Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software

29 November 2018 | By Thermo Fisher Scientfic

Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.

whitepaper

Application note: Transforming your bioanalysis operations – is a lack of insight slowing you down?

29 November 2018 | By IDBS

Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.

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Informatics