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SPIRAL device offers safer, smarter drug delivery to the brain
Scientists have created a flexible brain implant, called SPIRAL, capable of delivering drugs to multiple regions with pinpoint accuracy.
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Molecular biology
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Improving brain resilience: Rab proteins and future treatments
New research has discovered how Rab proteins control the delivery of critical supplies to strengthen neural connections, providing researchers with important insights into memory formation and potential strategies for Alzheimer’s resilience.
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How medications in waterways are encouraging antibiotic resistance
New research has discovered that mixtures of everyday medications in the environment can promote antibiotic resistance, offering new insights that could influence future drug discovery and environmental policy.
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How nanocarriers and VLPs are uniting to fight cancer
Innovations in nanomedicine are merging to redefine precision oncology. From virus-like particles to magnetic nanoparticles, integrated delivery systems are showing powerful potential for new, targeted cancer treatments.
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The predictive validity crisis: Pharma’s productivity paradox – Part I
Drug discovery now costs 100 times more per FDA-approved drug than in 1950, despite vast advances in biology and computing. The core problem is the collapse of predictive validity in preclinical models, which sits at the heart of pharma’s productivity paradox.
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Sperm ‘switch’ discovery could lead to new fertility therapies
Scientists have discovered the molecular ‘switch’ that powers sperm for fertilisation, which could potentially lead to new infertility treatments.
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DARG cells may drive neurodegeneration in progressive MS
Scientists have discovered a rare type of brain cell that appears to drive the chronic inflammation seen in progressive multiple sclerosis – which could potentially lead to new disease-modifying therapies.
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DNA repair secrets of naked mole-rats may guide new drug discovery
New research has demonstrated how tiny tweaks in a DNA-sensing enzyme may hold the key to the naked mole-rat’s extraordinary lifespan – offering insights that could one day inform therapies for aging and age-related diseases.
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How smoking and alcohol shape mutations in our DNA
Researchers have refined a cutting-edge DNA sequencing tool that reveals how mutations accumulate in healthy tissues as we age, offering insights into the earliest stages of cancer development.
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HIV antibody 04_A06 almost neutralises all strains
A newly discovered antibody, 04_A06, has shown unprecedented effectiveness against HIV, neutralising 98.5 percent of tested strains and permanently suppressing the virus in humanised mice.
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New UCLA drug could restore heart and organ function
UCLA researchers have developed a monoclonal antibody, AD-NP1, that blocks ENPP1 to enhance heart repair and reduce scar tissue.
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c-Kit helps sweet cells survive and regenerate taste
A new study has demonstrated that sweet-sensing taste cells, protected by the protein c-Kit, survive nerve injury and drive the regeneration of taste buds.
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DDHD2 enables neurons to synthesise and burn fat for energy
Scientists have discovered that neurons can burn and make their own fats for energy – a finding that could lead to new treatments for rare and currently untreatable brain diseases.
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Advancing gene editing: the role of lipid nanoparticles in CRISPR delivery
CRISPR therapies depend on delivery and lipid nanoparticles are emerging as a more flexible and scalable option than viral vectors.
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Pemafibrate and telmisartan combo may reverse fatty liver
A new study shows that approved drugs, pemafibrate and telmisartan, when combined, can reduce liver fat and may lower cardiovascular risk in metabolic dysfunction-associated steatotic liver disease.
