news
Gene discovery indicates motor neurone diseases caused by abnormal lipid processing in cells
A new genetic discovery adds weight to a theory that motor neurone diseases are caused by abnormal lipid processing pathways inside brain cells.
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Omics
article
Providing new hope for rare disease using non-viral gene therapy
Viral vectors to deliver gene therapies are utilised by clinically approved therapies. However, this method is not the only option for advanced therapeutics. In this piece, Brent Warner, President, Gene Therapy at Poseida Therapeutics, discusses the balance between efficacy and safety in gene therapy, highlighting positive pre-clinical data for non-viral…
whitepaper
Whitepaper: CAR T-Cell analysis with modular antibodies using SpyTag protein ligation
Here Bio-Rad presents the generation of specific anti-CAR T-cell antibodies to show how CAR T-cell analysis benefits from our modular antibody assembly technology using SpyTag-SpyCatcher protein ligation.
podcasts
Episode 9 – rDNA detection with Dr Jorge Haller, Prevail Therapeutics & Dr Mark White, Bio-Rad
This podcast features an exploration of detecting host cell residual DNA in AAV vector production for gene therapy.
article
Spatial biology is the next life science revolution
Dr Richard Goodwin, Head of Imaging & AI, Clinical Pharmacology & Safety Sciences at AstraZeneca, explores the latest innovation in early therapeutic development – spatial biology.
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Drug Target Review – Issue 2 2022
In this issue are articles focusing on a novel stem cell therapy for hearing loss, how a non-linear chiroptical effect could aid drug discovery and the advantages of cryo-electron tomography for imaging research. Also included are pieces on gene therapy, spheroids and genomics.
news
New insights into how genetic factors affect body’s immune response in type 1 diabetes
The new study highlights 11 genes which could be considered as potential candidates for novel therapeutics for type 1 diabetes.
video
Podcast: Challenges for the bioanalysis of CAR-T Cells
Podcast discussion featuring CAR-T Cell therapy development and reviewing current challenges and future potentials for these cell therapies.
whitepaper
Bulletin: Cancer vaccines: getting ready for a decade of big breakthroughs and novel treatments
Hear from leading industry experts in this emerging field who discuss: challenges related to antigen and adjuvant selection, vaccine design, immune response improvement and future treatment options.
news
Researchers identify pathway that regulates lipid synthesis and contributes to tumour survival
In their latest study, researchers at Moffitt Cancer Center have shown that cancer cells in an acidic environment undergo lipid synthesis and accumulation.
whitepaper
Infographic: Overview of the CAR-T cell therapy workflow
Find out more about the CAR-T cell therapy workflow in this informative infographic from Bio-Rad Laboratories (CA, USA). Discover some of the challenges associated with CAR-T cell R&D as well as technologies and reagents used for bioanalytical analysis.
news
Integrating genomic data from different ancestries reduces bias in predicting disease risk
Researchers have developed a promising new tool that accurately uses genomic data to predict disease risk across diverse populations.
article
Closing the diversity gap in genomics
In this article, Drug Target Review’s Ria Kakkad explores the importance of diverse and inclusive samples in genomic studies with Assistant Professor Lindsay Fernández-Rhodes, Pennsylvania State University.
news
An epigenetic cause of miscarriages has been identified and cured in mice
Researchers have discovered that failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities.
news
Reducing sclerosis inflammation in mice
Researchers have been able to reduce the chronic inflammation associated with multiple sclerosis in a mice model of the disease, by administering one of the resolving lipid mediators of inflammation, Maresin-1.
