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Novel DNA-free virus-like particles deliver gene-editing proteins to animal models
Researchers have developed a new drug delivery system using virus-like particles to successfully transport gene-editing proteins in pre-clinical studies.
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Understanding the tau tangles in neurodegeneration could aid treatment discovery
Representing a breakthrough in better understanding how tau proteins cause neurodegenerative disease, scientists have mapped the tau interactome.
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Scientists unveil first molecular-level analysis of Omicron spike protein
Using cryo-electron microscopy, researchers have completed the world’s first molecular analysis of the SARS-CoV-2 Omicron spike protein.
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Janssen licenses its pan-influenza antibody to Leyden Labs
Janssen's monoclonal antibody CR9114, for the potential treatment of influenza, has been exclusively licensed by Leyden Labs for development and commercialisation.
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Memory T cells respond to SARS-CoV-2 Omicron variant, study shows
Research has shown that memory T cells formed following SARS-CoV-2 infection or mRNA vaccination respond to the Omicron variant.
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Researchers engineer protein assembly via artificial protein needles
Japanese researchers have formed ordered biological structures using protein needles, enabling protein self-assembly into lattice structures.
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Bristol Myers Squibb research reveals atomic structure of protein receptor CD47
New Bristol Myers Squibb research has revealed details about the structure of the protein receptor CD47, which helps protect cells from the human immune system.
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Successful liver model developed for research into UCD
Urea cycle disorders affect the liver’s ability to excrete urea from the body. To test potential therapeutics requires an accurate model – a hurdle that has now been successfully navigated thanks to a team of researchers in Switzerland.
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CRISPR activation screening: finding genes that interact with SARS-CoV-2
Dr Greg Neely, University of Sydney, explains how he and his team used pooled whole genome CRISPR activation screening to identify LRRC15 as a SARS-CoV-2 spike-interacting protein.
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Opportune identification of novel multiple myeloma target
During investigations into the tropical disease Buruli ulcer, researchers have instead identified a promising new avenue for potential treatments for multiple myeloma.
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Sino Biological deposits recombinant Omicron proteins and antibodies to BEI Resources
To support disease research, Sino Biological has deposited reagents for the Omicron variant to BEI Resources.
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Experimental mRNA HIV vaccine shows promise in pre-clinical studies
A new potential mRNA vaccine that delivers instructions for making two key HIV proteins has been tested in mice and rhesus macaques.
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Ingenious AI method for improved target identification
A research team based at Skoltech in Russia has developed an artificial intelligence-driven solution for highly accurate detection of efficacious binding sites to expedite drug discovery.
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Scientists discover compound to combat multidrug-resistant bacteria
Taking a novel approach to antibiotic discovery, researchers at Rockefeller University have hit upon a promising solution to the problem of superbugs – a pervasive threat in hospitals the world over.
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Scientists develop means to boost the power of CRISPR
The capability to edit genes has been transformative in opening therapeutic avenues for hitherto untreatable diseases and aiding biological insight. Scientists have now discovered a way to enhance this process using retrons, making the process more efficient and effective.
