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Identifying biomarkers for progressive supranuclear palsy

5 July 2024 | By Drug Target Review

Protein biomarkers in spinal fluid linked to PSP could enable earlier diagnosis and treatment for this neurological disorder.

news

Proteogenomics: finding targets for never-smoker lung cancer

3 June 2024 | By Drug Target Review

Through multi-omics analysis, researchers find that oestrogen signalling could be a target for never-smoker lung cancer cases.

whitepaper

Poster: Assays for DDX3, DDX5, DDX17, RIG-I, and MDA5

10 May 2024 | By BellBrook Labs

A panel of HTS assays was developed using the Transcreener platform to accelerate the development of selective helicase inhibitors.

whitepaper

Poster: Assays for PRMT5, MLL4, METTL3/14, & NSP14

7 May 2024 | By BellBrook Labs

AptaFluor SAH: A Homogenous, Universal Assay for Histone, RNA, & DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, & NSP14

news

Discovery of over 100 genomic loci linked to hypertension

1 May 2024 | By Drug Target Review

The study’s findings explain the genetic differences in people’s blood pressure, which could lead to personalised medicine approaches.

news

New single-cell lipidomics method may unlock cancer treatments

24 April 2024 | By Drug Target Review

A new method for a fragmentation-based identification of lipids could enable the study of cancer cells in detail not seen before.

news

Using omic data to develop and validate biomarkers of ageing

22 February 2024 | By Drug Target Review

Researchers highlight the need for considering biomarkers alongside other health outcomes, as well as the need for omic data standardisation.

news

Multi-omic approach classifies biomarkers for paediatric sepsis

8 February 2024 | By Drug Target Review

Researchers have discovered potential biomarkers to identify paediatric sepsis progression stage, enabling more targeted treatment.

news

Targeting GBA gene variants for treating Parkinson’s disease

30 January 2024 | By Drug Target Review

A new project plans to elucidate the relationship between the glucosylceramidase beta gene and Parkinson’s disease.

whitepaper

Whitepaper: Targeting kinases in the innate immune response

24 January 2024 | By BellBrook Labs

The guide provides examples of how Transcreener allowed rapid assay development to enable screening for kinases in innate immune pathways.

news

Off-switches developed for CRISPR-Cas3 technologies

22 January 2024 | By Drug Target Review

AcrlC8 and AcrlC9 prevent the CRISPR-Cas3 machine from binding to its DNA target site, providing a safer way to engineer the genome.

news

Studying the effects of 3D genome organisation on gene silencing

19 January 2024 | By Drug Target Review

Researchers explored the effects of loops and 3D genome organisation on gene silencing, and found that ‘cohesinopathies’ may be linked it.

article

Using proteomics to overcome glioblastoma resistance

17 January 2024 | By Ellen Capon (Drug Target Review)

Using an AI algorithm to predict glioblastoma’s most active kinase, researchers hope for a next-generation precision therapy targeting resistant cancers.

article

How AI is accelerating the future of precision medicine

12 January 2024 | By Ellen Capon (Drug Target Review)

Dr Ketan Patel, Clarivate, shares his insights about the use of Real-World Data and genomic biomarker data and discusses how researchers can use these to better detect and diagnose diseases.

news

Unexpected patterns in DNA mutations identified

11 January 2024 | By Drug Target Review

Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.

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