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Multi-omic approach classifies biomarkers for paediatric sepsis

8 February 2024 | By Drug Target Review

Researchers have discovered potential biomarkers to identify paediatric sepsis progression stage, enabling more targeted treatment.

news

Targeting GBA gene variants for treating Parkinson’s disease

30 January 2024 | By Drug Target Review

A new project plans to elucidate the relationship between the glucosylceramidase beta gene and Parkinson’s disease.

whitepaper

Whitepaper: Targeting kinases in the innate immune response

24 January 2024 | By BellBrook Labs

The guide provides examples of how Transcreener allowed rapid assay development to enable screening for kinases in innate immune pathways.

news

Off-switches developed for CRISPR-Cas3 technologies

22 January 2024 | By Drug Target Review

AcrlC8 and AcrlC9 prevent the CRISPR-Cas3 machine from binding to its DNA target site, providing a safer way to engineer the genome.

news

Studying the effects of 3D genome organisation on gene silencing

19 January 2024 | By Drug Target Review

Researchers explored the effects of loops and 3D genome organisation on gene silencing, and found that ‘cohesinopathies’ may be linked it.

article

Using proteomics to overcome glioblastoma resistance

17 January 2024 | By Ellen Capon (Drug Target Review)

Using an AI algorithm to predict glioblastoma’s most active kinase, researchers hope for a next-generation precision therapy targeting resistant cancers.

article

How AI is accelerating the future of precision medicine

12 January 2024 | By Ellen Capon (Drug Target Review)

Dr Ketan Patel, Clarivate, shares his insights about the use of Real-World Data and genomic biomarker data and discusses how researchers can use these to better detect and diagnose diseases.

news

Unexpected patterns in DNA mutations identified

11 January 2024 | By Drug Target Review

Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.

news

Using proteomics to predict long-term disability outcomes in MS

10 January 2024 | By Drug Target Review

Data from protein analyses, combined with data from patient journals, enabled the discovery of proteins that predict disease progression.

article

A Guide to DNA Damage Response and Innate Immunity

10 January 2024 | By BellBrook Labs

In this guide, we provide an overview of the DDR and innate immune pathway and describe Transcreener Assays and Assay Systems for key targets.

news

Discovery enables further investigation into new ligases

4 January 2024 | By Drug Target Review

Researchers have developed a new PROTAC that activates the protein degradation system and binds to a previously inaccessible ligase.

article

Drug Target Review – Issue 4 2023

21 December 2023 | By

A new Drug Target Review issue is now ready to download! This issue features articles on CRISPR, personalised medicine and screening.

news

New algorithm identifies a novel CRISPR-Cas system

24 November 2023 | By Drug Target Review

Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.

Brain organoids in detail: structural details of organoids (yellow and red) and organoid cells (blue and green)

news

Incorporating microglia into brain organoids

16 November 2023 | By Drug Target Review

iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.

news

Protective mutation found in kidney disease gene

17 October 2023 | By Drug Target Review

A new discovery about a different protective genetic mutation in apolipoprotein L1 could have major implications for kidney health.

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