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Incorporating microglia into brain organoids
iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.
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Omics
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Protective mutation found in kidney disease gene
A new discovery about a different protective genetic mutation in apolipoprotein L1 could have major implications for kidney health.
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ebook: Maximizing preclinical confidence in target efficacy and safety
This ebook outlines Euretos’ approach to target discovery and indication expansion. Whilst also discussing data-driven target selection.
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Drug Target Review – Issue 3 2023
A new Drug Target Review issue is now ready to download! This issue features articles on vaccine development, artificial intelligence and organoids.
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Novel based editors developed
Researchers have developed a novel based CRISPR-free base editing system named CyDENT, which enables precise base editing.
webinar
Bridging the gap: using organ-on-a-chip as an experimental tool to develop (cost) effective therapeutics
25 July 2023 | By CN Bio
The webinar will explore primary concerns in drug discovery development and why drugs fail.
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A structural insight into HIV drug-resistance mechanisms
New Salk Institute, US, research could lead to the development of new HIV therapeutics that overcome resistance to existing drugs.
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Rare cause of hereditary cancer missed in younger patients
US investigators find that some cases of Lynch syndrome, the most common hereditary cancer condition, are missed in younger patients under current screening guidelines.
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Advancing directed protein evolution technology
Drug Target Review's Ria Kakkad spoke with Victoria Goldenshtein at PEGs Europe, about her lab’s novel in vitro library display platform for directed protein evolution called GRIP display – gluing RNA to its proteins.
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How do cells control the secretion of mucin and insulin?
Spanish researchers looking at two crucial proteins uncover how cells release mucin and insulin, leading to new methods to reset deregulation.
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Application note: How to improve glycoform and glycopeptide coverage for mucin preparations
Here we explore using a mucin-selective protease for tryptic-digest sample preparation of two mucin proteins and assess its potential to improve detecting glycoforms and glycopeptides.
news
New insights into influenza A’s infiltration of host cells
US researchers have made a significant breakthrough in understanding how the influenza A virus takes over host cells while minimising damage to itself. By studying the protein PA-X, they found that the virus uses a surgical strike approach, selectively degrading host cell RNA while preserving its own replication, shedding light…
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The role of CRISPR in microbiome engineering breakthroughs
Dr Jakob Krause Habber and Dr Richard Fox will explore the applications of CRISPR in microbiome engineering and how it can be used to overcome the bottleneck of human microbiome research.
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Drug Target Review – Issue 2 2023
A new Drug Target Review issue is now ready to download! This issue features articles on cell and gene therapy, imaging and screening.
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The genetic modifier approach: identifying the right target for rare diseases
In this article, Dr Vincent Blomen, Senior Director of Target Discovery at Scenic Biotech, takes us through the realm of rare diseases. In the case of most of these diseases, a singular genetic anomaly often reigns supreme, yet its impact on patients can be vastly divergent. Enter modifier genes, the…