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Novel screening method identifies lead molecule for GPCR dimerisation
The new high-throughput screening method identified nine lead molecules for rhodopsin dimerisation that may lead to next-generation medicines.
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“Sleeping” cancer cells could prevent tumour metastasis
A new study prevented the growth of metastatic tumours in mice by forcing cancer cells into a dormant state, pointing to novel treatments.
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Single molecule from plant used by Native Americans may treat diarrhoea
Scientists unveil the role of KCNQ2/3 using a functional screen of 40 native US plants and identify nine extracts that could treat diarrhoea.
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Ncardia secures more than $60 million to enhance and expand leading iPSC offerings
Ncardia has formed a strategic partnership with Kiniciti to build GMP capabilities to support iPSC cell therapy platforms and human cell-based in vitro discovery services.
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Human iPSC-derived cardiomyocytes for cardiac proarrhythmic risk assessment
Following Drug Target Review's webinar supported by Eurofins, speaker Dr Verena Albert answers the questions posed by the audience during the live event.
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Capturing biological complexity to empower biomarker discovery
27 October 2021 | By Takara Bio
Watch this free one-hour session to discover how refined cell atlases can provide comprehensive roadmaps for health and disease.
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Whitepaper: Phenotypic and functional CAR-T cell characterisation
This whitepaper overviews phenotypic and functional characterisation of CAR-T cells with advanced flow cytometry and live-cell analysis.
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Algorithm identifies cancer drugs to treat pulmonary hypertension
Scientists have identified potential cancer drugs to treat pulmonary hypertension using experimental and computational approaches.
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New antibiotic a possible alternative to treat Lyme disease
The antimicrobial hygromycin A was shown to clear Lyme disease in mice, representing a promising therapeutic against the disease.
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Highly potent antiviral against dengue could prevent spread of virus
A new antiviral has shown promise against the dengue virus in mice and has the potential to be used as a preventative measure.
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Neurolysin shown to be potential drug target for ischemic stroke
Researchers are identifying molecules that interact with neurolysin, a peptidase that helps protect the brain against stroke.
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Pre-clinical trials to test if psychedelic drugs reduce alcohol consumption
Landmark pre-clinical studies to investigate whether psychedelic derivatives can reduce alcohol consumption have been initiated.
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Application note: Validation of identified through AI
Targets for drug discovery can be identified with AI but require validation in vitro. Here’s how this can be done, using hiPSC technology.
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Leveraging innovative strategies for speedy cell line development
1 October 2021 | By Sartorius
Watch this roundtable of industry experts as they discuss technologies, best practices and strategies for delivering robust, stable, high-yielding cell lines to accelerate and streamline the drug discovery process.
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Targeting SARS-CoV-2 replication with inhibitors of lipid metabolism
One approach towards efficient drug targeting efforts for COVID-19 is to repurpose medicines developed for other diseases. Here, Professor Christopher Basler outlines a recent study, published in Cell Reports, where scientists from the Institute for Biomedical Sciences at Georgia State University, US, in collaboration with industry partners, developed assays to…