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Screening

Hit discovery for GPCRs: HTS or virtual screens?

8 April 2021 | By Beacon Discovery

Watch our on-demand webinar and learn from an industry expert regarding GPCR virtual screening approaches and challenges and much more.

Article: Defeating COVID-19: The science behind a new ELISA

whitepaper

Article: Defeating COVID-19: The science behind a new ELISA

6 April 2021 | By Bethyl Laboratories

Discover how a new ELISA against S1-RBD for COVID-19 seroconversion detection can accelerate discovery to facilitate vaccine breakthroughs.

news

X-ray screening reveals two promising SARS-CoV-2 drug candidates

6 April 2021 | By Victoria Rees (Drug Target Review)

Using a high-brilliance X-ray lightsource and protein crystallography, researchers have identified two drugs that inhibit the main protease of SARS-CoV-2.

High-throughput experimentation and lab automation

article

Expanding accessible chemical space through automated high-throughput experimentation

6 April 2021 | By Dr Sam Liver (The Rosalind Franklin Institute)

Dr Sam Liver, Manager of the High-Throughput Molecular Discovery Laboratory at the Rosalind Franklin Institute, explains how lab automation in the form of machine learning and high‑throughput experimentation (HTE) can be implemented to enhance productivity in autonomous molecular discovery.

news

New in vitro assay developed to test potential NASH drugs

1 April 2021 | By Victoria Rees (Drug Target Review)

An assay that combines 3D disease models and automated AI-based fibrosis quantification could accelerate NASH drug discovery.

article

Drug Target Review Antibodies ebook 2021

31 March 2021 | By Drug Target Review

Within this ebook, find articles on how a lead bNAb candidate was identified to combat COVID-19 and why antibodies could present the answer to HIV treatment and vaccines.

Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments

whitepaper

Application note: Effectiveness of CRISPR‑Cas9 using pools of synthetic crRNAs in high-content analysis screening experiments

31 March 2021 | By Horizon Discovery

In this application note, discover how pools of synthetic crRNAs can produce a phenotype as strong as, or stronger, than any one of the component crRNAs in arrayed CRISPR screening experiments.

article

A novel assay to reveal cyclic peptides with affinity to ubiquitin

31 March 2021 | By Victoria Rees (Drug Target Review)

Although macrocyclic peptides make for promising pharmaceutical candidates, screening for lead peptides has proved difficult for scientists. In a new study, researchers at the Technion-Israel Institute of Technology addressed these challenges by developing a novel high-throughput screening assay for cyclic peptides with affinity to the ubiquitin protein. Drug Target Review’s…

A cost, time and labour-saving protein purification platform

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Product hub: A cost, time and labour-saving protein purification platform

31 March 2021 | By GenScript

In February 2021, US biotech company GenScript launched an updated version of its semi-automated system, AmMag™ SA Plus.

article

COVID-19 drug targets and cell-based assays

30 March 2021 | By Alp Tegin Sahin (Kadir Has University), Sheraz Gul (Fraunhofer Institute)

The length of time between the administration of a COVID-19 vaccine and evidence of a robust immune response to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) means that treatments are still required. In this article, Sheraz Gul and Alp Tegin Sahin explore the various therapeutic targets that have been identified…

Metagenomic analysis of the microbiome with MagMAX

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Application note: Metagenomic analysis of the microbiome with MagMAX

26 March 2021 | By Thermo Fisher Scientfic

The isolation of microbial DNA is a key prerequisite for determining the microbiome profile of each body habitat.

article

Drug Target Review Assays ebook 2021

26 March 2021 | By Drug Target Review

In this ebook, find articles exploring some of the assays used to identify the most promising COVID-19 drugs and discussing the development of a novel assay to reveal potential peptide therapeutics for cancer.

podcasts

Episode 1 – Dr Sri Gopal, Janssen Pharmaceuticals

26 March 2021 | By Drug Target Review

Listen along to learn more about drug development for schizophrenia from Dr Sri Gopal, Head of Psychiatry R&D for Janssen!

article

Drug Target Review – Issue 1 2021

25 March 2021 | By Drug Target Review

In this issue, find articles discussing how high-throughput experimentation can enhance automated molecular discovery, why bNAbs present a promising COVID-19 treatment and how a novel rhinovirus vaccine was developed. Also included are features on immuno-oncology, cell line development and assays.

article

Identifying a novel treatment for heart attacks

25 March 2021 | By Victoria Rees (Drug Target Review)

Professor David Merryman explains how his team targeted the serotonin 2B receptor in animal models to preserve cardiac function six weeks after a heart attack.

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Screening