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Two compounds identified as circadian clock modulators
Researchers have developed two small molecules which target two components of the circadian rhythm and could be used to lengthen the body clock.
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Screening
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Organoids for the development of drugs and diagnostics for NASH
Organoids at different stages of non-alcoholic steatohepatitis (NASH) progression have been created to help in drug design and identification of diagnostic biomarkers.
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AI technology to screen existing drugs for use against COVID-19
A collaboration aims to utilise a compound library of 15,000 clinically-ready molecules and screen then against three COVID-19 targets.
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Video: Improve Traceability with TRACKMAN® Connected
Boost your experiment efficiency, improve traceability, and get immediate reproducibility with Gilson’s TRACKMAN® Connected.
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Video: TRACKMAN® Connected overview
TRACKMAN® Connected is a tablet with accessories and apps that makes pipetting on microplates faster with greater traceability and reproducibility.
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Nafamostat inhibits SARS-CoV-2 infection, preventing COVID-19 transmission
Researchers have demonstrated that Nafamostat mesylate (Fusan) can inhibit SARS-CoV-2 Spike protein-initiated membrane fusion at concentrations likely achievable and safe in patients.
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HTS used to reveal anticancer properties of cannabinoid combinations
Researchers have used high-throughput screening to discover the best combinations of purified cannabinoids against gastrointestinal cancer cells.
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ebook: Habitat for disease – disrupting the tumour micro-environment
No tumour prevails on its own. Rather, every tumour needs a community to thrive.
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Laboratory automation in early drug discovery
The future of drug discovery lies in an automated world where the workflows for biological assays, chemical synthesis and data analysis are connected by flexible, mobile and modular hardware, integrated with software solutions that will interface with scientists for increased efficiency and productivity (the realisation of Industry 4.0). This article…
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Application note: A rapid method to quantitatively screen bispecific antibodies using Protein A and HIS1K biosensors
Scientists at Celgene Corporation developed a screening process incorporating the Octet® HTX system to identify pools and clones with higher concentrations of bispecific antibodies. Higher throughput was achieved from the multiple simultaneous measures possible on the Octet system and rapid assay times, such as binding optimisation in only 10 minutes.…
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Cornea-on-a-chip could allow for more accurate ophthalmic drug testing
Researchers have developed a device which mimics how blinking and tear movement effect the cornea for use in testing ophthalmic drugs and ocular research.
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Using CRISPR-Cas9 to identify new gene drug targets
Researchers have used CRISPR-Cas9 to screen the genome for possible targets that could be used in potential treatments for muscular dystrophy.
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Screening reveals rocaglate compounds kill C. auris
Researchers have screened over 2,000 compounds to discover that rocaglates effectively combat C. auris, offering a potential new treatment.
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Article: The digital revolution – protect your pipetting data
Connected lab tools that digitally record each step researchers make, like Gilson’s TRACKMAN® Connected, help create traceable, centralised data.
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Expert view: How automation can improve cell stability and productivity in cell line development
During cell line development, key attributes such as cell productivity, stability and monoclonality are required before progressing cells for manufacturing.
