Screening

Experimental treatment slows prion disease

5 August 2019 | By Rachael Harper (Drug Target Review)

A new experiment has not only slowed the progression of the prion disease, scrapie, it also extended the lives of prion-infected mice

Molecular Devices introduces the FLIPR^® Penta system

2 August 2019 | By Molecular Devices

Molecular Devices, LLC, today announced the launch of the next generation of its FLIPR® Penta High-Throughput Cellular Screening System.

Motor neuron disease electrical signalling pathways mapped

1 August 2019 | By Victoria Rees (Drug Target Review)

A study has used EEG to investigate the neuron networks that act abnormally in the condition, providing a significant step in the search for treatments.

Newly discovered signal could lead to anti-cancer therapies

31 July 2019 | By Drug Target Review

Researchers have newly found that protein CD24 acts as a defensive signal and is used by cancer cells to protect themselves.

Application note: Monitoring Aggregation of Antibody-Drug Conjugates

30 July 2019 | By Enzo Life Sciences

Prediction of Aggregation Propensity and Monitoring of Aggregation of Antibody-Drug Conjugates (ADC).

Encouraging drug discovery and therapeutic targets for dementia

26 July 2019 | By Victoria Rees (Drug Target Review)

A review has been published by experts in neurodegeneration research, detailing six ways to improve dementia research. This article investigates one of these suggestions, focusing on how we can improve drug target identification.

Screening identifies gene which protects cells from Zika virus

26 July 2019 | By Victoria Rees (Drug Target Review)

Researchers used screening to discover genes that protect the body against the Zika virus, which could inform potential therapies against the virus.

Chemical synthesis and biological screening combined on chip

16 July 2019 | By Victoria Rees (Drug Target Review)

Researchers have developed a chip which facilitates and accelerates active substance production, characterisation and biological effectiveness.

Intellicyt iQue3 – Faster, Smarter Flow Cytometry

8 July 2019 | By IntelliCyt Corporation

This advanced flow cytometry platform is a complete instrument, reagents and software solution streamlined to rapidly generate results not just data.

Titian Software Ltd

Video: Ethical and regulatory use of biospecimens in the EU

1 July 2019 | By BioIVT

Unique considerations surrounding the bureaucracy and oversight in the use of human biospecimens in the European Union.

Video: Multiplex IHC and digital analysis for immuno-oncology

1 July 2019 | By BioIVT

High content data derived for complex immuno-oncology research facilitates a deeper understanding of the tissue microenvironment.

Compound and fragment screening by native mass spectrometry

14 June 2019 | By Nicola Burgess-Brown, Rod Chalk

Native mass spectrometry has the potential to be a fast, simple, highly sensitive and automatable technique for compound screening in drug design and discovery. In this article, Rod Chalk and Nicola Burgess-Brown discuss the key attributes of native mass spectrometry and reasons why it is not yet widely employed.

Screening and beyond in drug discovery

14 June 2019 | By Sheraz Gul (Head of Drug Discovery at the Fraunhofer Institute for Molecular Biology and Applied Ecology)

Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that only a small proportion of drug discovery projects are successfully progressed to such a stage. A major cause of this is the lack of comprehensive profiling of compounds prior to…

First blood-brain barrier chip using stem cells developed

13 June 2019 | By Drug Target Review

Researchers have, for the first time, duplicated a patient's blood-brain barrier (BBB), creating a human BBB chip with stem cells.