whitepaper
HCA: Phenotypic fingerprint of cellular function
High-content analysis app note: Phenotypic fingerprint of cellular function following gene editing by high-throughput imaging acquisition and analysis.
List view / Grid view
Screening
whitepaper
HCA Application note: New way of measuring synaptic function
High-content analysis: monitoring neurite morphology and synapse formation in primary neurons for neurotoxicity assessments and drug screening.
article
Why do we have no effective treatments for osteoarthritis?
Osteoarthritis (OA) is a painful and debilitating disease of articular joints.1,2 Its clinical prevalence is as high as 21.6 percent of the population in the United States,3 which constitutes direct health costs of over 80 billion US dollars annually.4
article
Realising the promise of laboratory automation in biomedical research
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
video
Video: High content imaging to examine RNA in cancer cells
Dr Kaylene Simpson, Peter MacCallum Cancer Center, describes their research using high content imaging to examine RNA in cancer cells.
video
Video: 3D Culture Screening
Michael Johnson and his team at Visikol talk about the work they do as a contract research organization on 3D Cell Cultures and how they utilize High-Content Analysis / Screening to generate insights.
article
The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays
Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.
article
Assays In-Depth Focus 2019
In this In-Depth Focus: the importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays, and why do we have no effective treatments for osteoarthritis?
news
Non-invasive imaging for small airway lung disease
A non-invasive method of imaging tiny bronchioles in the lungs of chronic obstructive pulmonary disease means patients could detect the disease earlier...
article
Drug Target Review – Issue 1 2019
In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.
article
Network-driven drug discovery
Target-driven drug discovery, in which the starting point is a specific protein target hypothesised to play an important role in disease, has been the dominant paradigm for the last few decades. However, phenotypic-driven drug discovery, which does not rely on a specific target hypothesis, is starting to regain traction for…
news
Machine-learning model to analyse protein sequences
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
news
Potential EBV-associated cancer treatment in small molecule inhibitors
A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
news
Protein marker in response to brain cancer therapy
An extremely powerful MRI scanner was used to image proteins in the brain of cancer patients and has shown that protein content correlates with treatment...
news
Genetic study confirms that numerous genes contribute to Tourette’s syndrome
A meta-analyses of a number of studies has found that variants in numerous genes work together to contribute to Tourette's syndrome...
