podcasts
Small molecules for regenerative medicine
In this episode, we discuss how new insights into stem cell biology are leading to novel therapeutics in regenerative medicine beyond cell therapy.
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Stem Cells
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The evolution of cell therapy to address unmet medical needs
We had the privilege of interviewing Brian Culley, CEO of Lineage Cell Therapeutics. He discusses how Lineage’s pluripotent stem cell platform is extraordinarily advantageous, details two early-stage programmes addressing auditory and vision disorders and reveals how Lineage is choosing to target conditions that will make a real difference.
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Modelling the blood-brain barrier with organoids
The world’s first generation of human BBB organoids from hPSCs accurately replicated features of cerebral cavernous malformation.
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New brain organoids express proteins in a human brain-specific manner
Culture conditions during embryoid body formation can be enhanced to gain glia-associated proteins and neural network activity.
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ERRγ controls parietal cells generation and maturation from stem cells
Researchers uncover a genetic pathway of parietal cell development, which will enable a better understanding of stomach conditions.
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Chronic liver fibrosis mitigated by mouse hepatocytes
The new study provides proof of principle that functional liver cells can be grown in a different species, offering a potential solution to transplant shortage.
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How hematopoietic stem cells retain their regenerative potential
Researchers found that genetic depletion of cyclophilin A results in stem cells distinctively lacking intrinsically disordered proteins.
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Enhanced NPC cultivation furthers understanding of kidney disease
Induced NPCs facilitate the creation of patient-specific organoid models and improve identification of nephron targeted drugs.
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Improved method to control the generation of dopaminergic neurons
A synthetic antibody selectively activates the Wnt signalling pathway and directs stem cells to differentiate into neurons.
podcasts
Investigating the promising future of organoids
In this episode, we discuss the current advantages and limitations of using organoids, as well as where the field is heading.
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Accelerating cardiac regenerative therapy with HiPSC spheroids
Injections of cardiac spheroids into primate ventricles improved left ventricular ejection after four weeks.
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Optimising CRISPR gene editing of hard-to-transfect cells
CRISPR has transformed gene editing, but still presents challenges in hard-to-transfect cells, such as pluripotent stem cells and primary cells.1 The key to obtaining successful transfection in these cells lies in innovative workflows. Here Georges Müller, CEO and cofounder of SEED Biosciences, shares his perspective on why focusing on editing…
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Hereditary Alzheimer’s disease can be transferred via transplants
Transplant recipients of hematopoietic stem cells with a hereditary version of AD developed the disease at an accelerated rate.
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Blastoids enable greater understanding of human gastrulation
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.
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FGF2 and SOX17 enable more efficient stem cell differentiation
The discovery of two proteins that effectively mature hiPSCs into endothelial cells may have a range of research and clinical benefits.