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SVC112 molecule reduces effects of cancer stem cells with little toxicity
A study has shown that the SVC112 molecule can prevent cancer stem cells from producing more tumour cells in cell lines and mice, with no impact on healthy cells.
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Stem Cells
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Poster: Exosomes – Contents by Cell Type and Process
When exosomes were first discovered they were thought to be nothing more than cellular waste containers, but it is now thought that the integral membrane proteins, soluble proteins, and nucleic acid contained within exosomes can be taken up by cells and influence their function.
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Genes found to slow down the development of intestinal tumours
Scientists have found that when two specific genes are deleted in benign tumour tissue in the intestines, it more rapidly develops into a tumour that is more likely to become cancerous.
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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
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Accurate model of organ scarring created using stem cells in a lab
Researchers have developed a 'scar in a dish' model derived from human stem cells which mimics the progressive scarring that occurs in human organs and has lead to a drug candidate being identified to stop the progression of fibrosis.
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Application note: GMP Proteins for Therapeutic Manufacturing
Immune cell therapies, stem cell therapies, and regenerative medicine, often grouped into the category of advanced therapy medicinal products (ATMPs), offer some of the most revolutionary and exciting new approaches for treating human disease.
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Activating bone stem cells has potential therapeutic applications
A study has demonstrated that activating bone periosteal stem cells leads to increased bone healing in mice, presenting a potential therapeutic strategy.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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Medicine against bone disease found in Saussurea leaves
Isolated components found in the Saussurea controversa plant have antimicrobial and regenerative properties which could lead to a treatment for bone diseases.
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Researchers use imaging to reveal early stages of colon cancer
A study has demonstrated how mutations in early colon cancer prevail and grow into malignancies, using fluorescent imaging.
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Human heart-in-a-jar model to be developed
Researchers will create the first human heart-in-a-jar to study heart failure, identify new therapeutic targets and test novel treatments.
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Tendon stem cell discovery could lead to improvements in injury recovery
Researchers have discovered the existence of tendon stem cells, which could lead to improvements in treating tendon injuries, avoiding surgery.
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Video: Bioprocess systems for perfusion process development at small and bench scale
We present cell retention technologies suitable for small and bench scale bioprocessing.
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Video: Large-scale hiPSC-based drug development
From small-scale stem cell production to large-scale hiPSC-based drug development: The flexibility of stirred-tank bioreactors.