whitepaper
Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models
Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.
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Stem Cells
news
Stem cell study optimises bone marrow transplants
A study has shown how stem cells that are transplanted act in a different way to those ordinarily present, without a transplant...
whitepaper
Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
news
Tailoring treatment for acute myeloid leukaemia
Rapid drug response screening for leukaemia stem cells offers clues to relapse and to improving patient-specific therapies...
article
Application Notes supplement 2018
Researchers are always looking more effective and efficient ways of making their work more successful. In this supplement, some of our commercial partners share their data, detailing the application of their technology.
news
Nanoscale ‘tweezers’ for individual cell biopsies
Researchers have developed nanoscale 'tweezers' used to investigate single living cells, which could help to identify why healthy cells become diseased...
article
Under the microscope: CROs and microplate reader requirements
Contract Research Organisations rely on microplate readers for effective hit discovery. Ian Waddell, of Charles River Laboratories, explains what his needs are.
whitepaper
Application note: Production of human induced pluripotent stem cell-derived cortical neurospheres in the DASbox® Mini Bioreactor System
There is substantial interest in the scientific community in using human induced pluripotent stem cell (hiPSC)-derived neural cells to study basic mechanisms of brain development, neuronal function, and drug-induced effects. In vitro-generated brain organoids are promising models, because they show a remarkable degree of maturation and can be kept in…
article
Drug Target Review – Issue 4 2018
In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.
news
Advanced biomaterial improves stem cell therapy for strokes
Researchers in Spain have achieved functional recovery from a stroke after implanting silk fibroin hydrogels-encapsulated stem cells in stroke mice.
webinar
High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland
9 November 2018 | By Beckman Coulter
In this webinar you learn about a high throughput screening approach for mining of antibody repertoires in the context of biologics drug discovery.
news
Stem cell therapy with biodegradable scaffold
A biodegradable scaffold used to transplant stem cells and deliver drugs, could help in the treatment of brain diseases...
news
Skeletal stem cells de-differentiate to achieve extensive growth
Researchers in the U.S. have discovered that skeletal stem cells in the jaws of adult mice de-differentiate when tasked with regenerating large portions of bone and tissue.
news
GFAP gene mutation creates tangles in brain cells – cause of neurological disease
A recent study in the U.S. has identified how a mutation in the GFAP gene, which encodes for the GFAP protein, causes the tangles in brain cells associated with Alexander disease and may also impact other neurological diseases.
webinar
Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application
25 October 2018 | By NanoTemper Technologies
In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...