Stem Cells

Expert view: Assays to measure the potency of therapeutic antibodies used in combination with other drugs for Immuno‑Oncology treatments

6 September 2018 | By Roger Bosse (PerkinElmer)

Growing evidence reveals that using single immunotherapies to treat oncological disorders may lead to cancer-killing T-cell overdrive,initiating life-threatening autoimmune reactions including cytokinestorm; also known as hypercytokinemia or Cytokine Release Syndrome(CRS). Recently, checkpoint blockade using anti-programmed cell death1 (anti-PD-1) inhibitors became a prevalent approach for stimulatinganti-tumour immune system.

Eppendorf

Expert view: New developments in real‑time live‑cell analysis

5 September 2018 | By Del Trezise

Live-cell analysis is now a well-established method that is part of the everyday cell biologist’s armoury for understanding cell biology. For over a decade, the functionality, throughput, and ease of use offered by real-time live-cell analysis has provided a platform for accurate and reproducible cell biology analysis in multiple biomedical…

Intervertebral disc degeneration could be treated using mesenchymal stem cells

5 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers explored how mesenchymal stem cells could help to treat intervertebral disc degeneration by accelerating disc matrix remodelling...

3D liver tissue made from stem cells show promising support of liver function

5 September 2018 | By Drug Target Review

Stem cells transformed into 3D human liver tissue by scientists show promising support of liver function when implanted into mice with a liver disease...

Drug Target Review – Issue 3 2018

3 September 2018 | By Drug Target Review

In this issue: pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease, the evolving role of three dimensional in-vitro cell culture techniques in drug discovery, and NGS: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of genetic diseases.

NanoTemper Technologies

Beckman Coulter, Inc.

Recent advances in diagnostics and treatments – from small molecules to cellular therapies

14 August 2018 | By Bio-Techne

With recent advances in medicine, cellular therapies are one step closer to becoming a reality where re-programmed cells, tissues and organs can be used as therapeutic agents. This webinar discussed the journey of medical treatments from small molecule to cellular therapies...

Bio-Techne

New stem cell model to test treatments for neurodegenerative disorders

2 August 2018 | By Drug Target Review

The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...

UBR5 protein may reduce neurodegeneration in Huntington’s disease

27 July 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...

From fibroblasts to medicinal signalling cells: a paradigm shift in translational stem cell research

20 July 2018 | By Darius Widera, Jonathan Sheard, Thamil Selvee Ramasamy

Mesenchymal stem cells (MSCs) are fibroblast-like cells that give rise to mesenchymal derivatives including bone, fat and cartilage cells. In addition to the bone marrow, they can be readily obtained from adult vascularised peripheral tissues including adipose, olfactory, respiratory tissue, and peripheral blood.

Urine-derived stem cells as innovative platform for drug testing and disease modelling

20 July 2018 | By Audrey Ncube, James Adjaye (Heinrich-Heine-University), Lisa Nguyen, Lucas-Sebastian Spitzhorn, Martina Bohndorf, Shaifur Rahman, Wasco Wruck (Heinrich-Heine-University)

Kidneys are crucial for filtration of drugs and toxins and their proper function is essential for overall health. Unfortunately, due to disease and improper function, kidney transplantation or dialysis are necessary for millions of patients annually all over the world.1,2

Whitepaper: A guide to achieving better insight with accurate data

17 July 2018 | By IDBS

In today’s modern world, data is everywhere. This eBook will guide you through the steps of how to achieve more with accurate data.