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New organoid model of neuroendocrine tumours developed
NETs require epidermal growth factor to grow, meaning that inhibiting EGF receptors could treat these types of tumours.
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Stem Cells
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Astrocytes gain neural stem cell properties after brain injury
Astrocyte plasticity is correlated with upregulation of the Galectin 3 protein, which may greatly contribute to biomarker discovery.
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New gene found plays essential role in stem cell differentiation
Intestinal organoids allowed researchers to understand how Rnf43 and Daam1 influence the balance of stem cell renewal and differentiation.
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New technology optimises mesenchymal stem cell extraction
A continuous sorting technique of stem cells on a DLD microfluidic platform may greatly advance cell therapy.
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New colon organoids better resemble both healthy and diseased colons
Researchers have developed organoids with naturally occurring early-stage immune cells, which could lead to effective personalised treatment.
whitepaper
Handbook: Advanced flow cytometry handbook
Don’t miss out on the easier way to do flow cytometry. Learn how to bring speed, throughput, multiplexing and miniaturization, to your bench.
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Human organoid research offers insights into gut cell differentiation
How stem cells become enteroendocrine cells using gut organoids could have positive implications for many gastrointestinal diseases.
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iPSC-derived cells can augment remuscularisation of the heart
Researchers have improved the method of regenerating heart muscle after a heart attack using a combination of iPSC-derived cells.
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New research discovers gene mutations linked to prostate cancer
A study led by scientists from the Center for Genetic Epidemiology at the Keck School of Medicine of USC and USC Norris Comprehensive Cancer Center has made a significant leap in our understanding of aggressive prostate cancer.
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Insights into the critical initial phase of embryonic development
Researchers from the University of Helsinki and the National Institutes of Health (NIH) in the United States have made a new discovery: the ectoderm, one of the germ layers, does not lose its pluripotency during gastrulation, contrary to prior beliefs.
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Stem cell therapy to slow progression of multiple sclerosis (MS)
Autologous haematopoietic stem cell transplantation (aHSCT), a medical procedure typically employed in the treatment of blood cancers, holds promise as a potential therapy for individuals with relapsing-remitting multiple sclerosis (RRMS).
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ebook: Maximizing preclinical confidence in target efficacy and safety
This ebook outlines Euretos’ approach to target discovery and indication expansion. Whilst also discussing data-driven target selection.
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PCOS: stem cell-derived components
Polycystic ovary syndrome (PCOS) is a widespread endocrine disorder affecting millions of women worldwide, profoundly impacting their hormonal equilibrium, fertility, and overall quality of life. This enigmatic condition, characterised by diverse symptoms and complex underlying causes, has long eluded effective treatment.
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Drug Target Review – Issue 3 2023
A new Drug Target Review issue is now ready to download! This issue features articles on vaccine development, artificial intelligence and organoids.
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Decoding cell therapy variants with Dr Andy Bader
The field of cell therapy has emerged as a beacon of hope, promising transformative treatments for various diseases. Diving into the intricacies of this domain, this exclusive interview explores the distinctions between two key approaches – autologous and allogeneic cell therapies. We look at the nuances of cell sourcing, preclinical…