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Cell contacts in embryonic development determine cellular fate
Researchers have identified a positive feedback loop between the duration of cell-cell contacts and the specification of a cell's fate...
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Stem Cells
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Stem cell line offers expanded potential for research and treatments
Researchers have created Expanded Potential Stem Cells that have greater potential for embryonic development than current stem cell lines...
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EUTCD-Grade lines: an innovative approach to creating and supplying clinical hESC lines
The ever-increasing pressure to turn bench-top discoveries into new therapies has led to the re-purposing of embryonic stem cell lines, originally intended for basic research, for clinical applications...
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Drug Target Review – Issue #3 2017
Included in this issue: The importance of industry partnerships; Calcilytics as potential novel therapeutic treatments to halt Alzheimer's disease; Accelerating neuroscience research with flow cytometry...
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New headquarters in Scotland strengthens drug discovery research
A provider of products and services for research in stem cells, drug discovery, human tissues and 3D cell culture has opened its European headquarters in Glasgow, UK...
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New marker could refine the process of producing hPSC-derived insulin cells
Scientists at the University of Copenhagen have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle to purify the cells whose fate is to become cells of the pancreas - including insulin producing cells.
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Targeting ‘broken’ metabolism in immune cells reduces inflammatory disease
Scientists have uncovered a way to ‘program’ immune cells to cause less damage to the body, by tapping into a ‘broken’ chemical pathway in inflammation.
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Miniature human hearts created from rat hearts
A miniature human heart, created by introducing human cells into the matrix of a whole rat heart, may make it easier to confirm basic science findings...
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Blood test for early detection of pancreatic cancer headed to clinic
A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research...
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Gut bacteria can help predict how body responds to fatty foods
Chemical signatures from gut bacteria which show up in urine can be used to predict how the body will respond to a 'junk' diet.
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Development by design methodology: the key to successful manufacturing of patient-specific cell therapies
Recognised as the next wave of medicine, cell therapies have made significant strides over the last several years. But such advancements can present unique challenges, especially as more products move out of the clinic and toward commercialisation. And unlike typical pharmaceuticals, cell therapies rely heavily on the manufacturing process to…
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Hidden herpes virus may play key role in MS and other brain disorders
The ubiquitous human herpes virus 6 (HHV-6) may play a critical role in impeding the brain's ability to repair itself in diseases like multiple sclerosis.
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Scientists discover how membrane necks get constricted and cut
Scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have succeeded in revealing a key mechanism of membrane deformation.
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Genetic DJ: Growing cells remix their genes
Moving genes about could help cells to respond to change according to scientists at the Babraham Institute in Cambridge, UK and the Weizmann Institute, Israel.
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First ‘haploid’ human stem cells could change the face of medical research
Research has yielded the first successful isolation and maintenance of haploid embryonic stem cells in humans.