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Targeting ‘broken’ metabolism in immune cells reduces inflammatory disease
Scientists have uncovered a way to ‘program’ immune cells to cause less damage to the body, by tapping into a ‘broken’ chemical pathway in inflammation.
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Stem Cells
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Miniature human hearts created from rat hearts
A miniature human heart, created by introducing human cells into the matrix of a whole rat heart, may make it easier to confirm basic science findings...
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Blood test for early detection of pancreatic cancer headed to clinic
A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research...
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Gut bacteria can help predict how body responds to fatty foods
Chemical signatures from gut bacteria which show up in urine can be used to predict how the body will respond to a 'junk' diet.
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Development by design methodology: the key to successful manufacturing of patient-specific cell therapies
Recognised as the next wave of medicine, cell therapies have made significant strides over the last several years. But such advancements can present unique challenges, especially as more products move out of the clinic and toward commercialisation. And unlike typical pharmaceuticals, cell therapies rely heavily on the manufacturing process to…
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Hidden herpes virus may play key role in MS and other brain disorders
The ubiquitous human herpes virus 6 (HHV-6) may play a critical role in impeding the brain's ability to repair itself in diseases like multiple sclerosis.
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Scientists discover how membrane necks get constricted and cut
Scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have succeeded in revealing a key mechanism of membrane deformation.
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Genetic DJ: Growing cells remix their genes
Moving genes about could help cells to respond to change according to scientists at the Babraham Institute in Cambridge, UK and the Weizmann Institute, Israel.
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First ‘haploid’ human stem cells could change the face of medical research
Research has yielded the first successful isolation and maintenance of haploid embryonic stem cells in humans.
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New gene mutations found in white blood cells in rheumatoid arthritis patients
Finnish researchers have found that an accumulation of gene mutations, similar to those typically seen in the development of cancer, also occur in some patients with rheumatoid arthritis.
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Blood cell discovery identifies patients with aggressive prostate cancer
Patients who have aggressive prostate cancer could be identified by a highly accurate and simple blood test, according to a new study.
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Nanoparticle aggregates for destruction of cancer cells
An international team has shown that it is possible to mechanically destroy cancer cells by rotating magnetic nanoparticles attached to them in elongated aggregates.
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Arming T-cells to channel aggression against cancer
Scientists have armed immune cells with a new surface molecule that causes them to respond aggressively when they encounter a protein that tumours actually use to camouflage themselves from the immune system. Researchers from the Helmholtz Zentrum München and various partners introduced the method in ‘Cancer Research’.
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‘Immunoswitch’ particles may be key to more effective cancer immunotherapy
Scientists have created a nanoparticle that carries two different antibodies capable of simultaneously switching off cancer cells’ defensive properties while switching on a robust anti-cancer immune response in mice.
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Researchers identify a key controller of biological machinery in cell’s ‘antenna’
St. Jude Children’s Research Hospital discovery of a regulatory enzyme working at the primary cilium could lead to treatments for the brain tumour medulloblastoma.
