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New counterintuitive approach to treating brain cancer
The loss of the tumour suppressor gene PTEN has been linked to tumour growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM).
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Stem Cells
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Researchers find key molecule that could lead to new anaemia therapies
Researchers find key molecule that could lead to new therapies for anaemia and other iron disorders.
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Using single-cell RNA sequencing to track stem cell development
Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal.
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New lung ‘organoids’ in a dish mimic features of full-size lung
'Mini organs' may aid in understanding and treating respiratory diseases.
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Lung study in mice points to new therapies to treat critical illness
Scientists have pinpointed a chemical signal that worsens inflammation linked to a life-threatening lung condition. The discovery could eventually lead to new therapies for this disease, which can be fatal for up to half of those affected.
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Immune cells found to be derived from specialised progenitors
Dendritic cells are gatekeepers of immunity and crucial for the detection and initiation of immunity against pathogens and foreign substances. Up to now, dendritic cell subtypes were thought to develop from one common progenitor. New findings from a team of researchers show with single cell resolution that this important component…
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New genes identified in children linked to stress & bipolar disorder
Genetic alterations that can be modulated by stress have been identified in children at high risk for bipolar disorder, according to a new study...
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
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New cell separator could advance cancer and Alzheimer’s research
A new cell separator that began life as a tinfoil and epoxy glue prototype built with supplies from a University shop could revolutionise stem-cell and regenerative cell-based therapies.
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New chlamydia drug targets discovered using CRISPR and stem cells
Scientists have created an innovative technique for studying how chlamydia interacts with the human immune system...
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Cancer-causing virus masters cell’s replication & immortality
Viruses are notorious for taking over their host's operations and using them to their own advantage. But few human viruses make themselves quite as cozy as the Epstein-Barr virus, which can be found in an estimated 9/10 humans without causing any ill effects. That is, until this virus causes mononucleosis…
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Pathways leading to beta cell division identified, may aid diabetes treatment
Pancreatic beta cells help maintain normal blood glucose levels by producing the hormone insulin -- the master regulator of energy (glucose). Impairment and the loss of beta cells interrupts insulin production, leading to type 1 and 2 diabetes.
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Researchers print stem cells using 3D bioprinter to form cartilage
A team of researchers have generated cartilage tissue by printing stem cells using a 3D-bioprinter...
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Removing old cells could extend joint health & stop osteoarthritis
In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.
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Novel method to detect toxic effects of chemicals could reduce need for animal testing
Traditional toxicological investigations performed on animals (in vivo) are expensive, time-consuming and may cause animal suffering.
