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Beyond the lab: artificial intelligence

28 February 2024 | By Drug Target Review

Amidst the transformative era of AI in drug discovery, this report focuses on recent advancements, notably the development of highly accurate drug target models, and how AI is revolutionising precision in identifying drug targets.

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Key insights into vaccine development for herpesviruses

27 February 2024 | By Drug Target Review

Researchers found that the D48 antibody neutralised HSV-1 virus infection, which could lead to broad-spectrum drug and vaccine development.

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Uncovering the changes to β-cells at the onset of type 1 diabetes

27 February 2024 | By Drug Target Review

A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.

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Development of a new recombinant flu vaccine

26 February 2024 | By Drug Target Review

A new vaccine, based on a nanoliposome that promotes proteins to be displayed on its surface, results in potent vaccine efficacy.

Mitochondrial disease Mitochondrial DNA 3D rendering

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Improved gene editing method for mitochondrial genetic diseases

26 February 2024 | By Drug Target Review

Researchers have developed the world’s first animal model with A-to-G mtDNA edits achieved using engineered TALEDs.

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New cell culture model reveals neurodegeneration mechanisms

23 February 2024 | By Drug Target Review

Researchers discovered that NPTX2 protein accumulated in cells containing abnormal TDP-43 in FTD and ALS patients.

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DOP-targeted therapies could exert significant anxiolytic effects

23 February 2024 | By Drug Target Review

Researchers have uncovered the role of the PL-BLA neuronal axis and its potential function in DOP-mediated anxiolytic effects.

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4PY found to directly trigger vascular inflammation

21 February 2024 | By Drug Target Review

Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.

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Potential new therapies for primary open-angle glaucoma

20 February 2024 | By Drug Target Review

Researchers have gained a better understanding of the genes and biological processes that could influence POAG pathogenesis.

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Mitigating oxidative stress in neurodegenerative diseases

20 February 2024 | By Drug Target Review

Researchers have found that using protein-like polymers to inhibit the Keap1/Nrf2 PPI is a powerful therapeutic strategy.

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The molecular mechanisms of lenacapavir revealed

19 February 2024 | By Drug Target Review

Researchers discover a mechanism that could be exploited for targeting other viruses that build capsids to hide from host defences.

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New antibiotic overcomes antimicrobial mechanisms

19 February 2024 | By Drug Target Review

Researchers have created a novel molecule, which has an improved ability to bind to bacterial ribosomes, with a completely synthetic system.

Women scientists nurses and doctors fighting against coronavirus. Feminist steminist illustration. Female Doctors, nurses and scientists together.

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Women in Stem with Dr Beate Mueller-Tiemann

19 February 2024 | By Dr Beate Mueller-Tiemann (Cytiva), Taylor Mixides (Drug Target Review)

Introducing Dr Beate Mueller-Tiemann, whose journey spans continents and disciplines, with a passion for biochemistry and molecular biology since her high school days. From elucidating pivotal proteins in cancer to monoclonal antibody discovery, Dr Mueller-Tiemann's contributions have not only transformed our understanding of diseases but have also fuelled research in…

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Identification of an immune biomarker for liver cancer

16 February 2024 | By Drug Target Review

New immunotherapies may be developed for patients with HCC associated with steatotic liver disease, with TREM1 suggested as a target.

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Uncovering the bidirectional relationship between PD and DM

16 February 2024 | By Drug Target Review

Single-cell RNA analysis provides an immunological explanation for the association between periodontitis and diabetes mellitus.

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