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Insights into the toxicological effects of nanoparticles

1 March 2024 | By Drug Target Review

Researchers have developed a system that enabled quantitative assessment of cytotoxicity of SiNPs in human hepatoma cells.

article

The future of cancer immunotherapy with Elicio Therapeutics

1 March 2024 | By Dr Christopher Haqq (Elicio), Taylor Mixides (Drug Target Review)

In this exclusive interview with Dr Christopher Haqq, Executive Vice President, Head of Research and Development, and Chief Medical Officer of Elicio Therapeutics, we explore the latest in Cancer Immunology Research. The study highlights the promising preclinical data demonstrating the potential of TCR-T cell therapy in combination with lymph node-targeted…

news

Potential for targeted therapies based on the gigaxonin pathway

29 February 2024 | By Drug Target Review

Researchers have discovered that higher expression of gigaxonin suppresses aggressive growth of human head and neck cancer cells.

Women scientists nurses and doctors fighting against coronavirus. Feminist steminist illustration. Female Doctors, nurses and scientists together.

article

Women in Stem with Dr Amber D. Van Laar

29 February 2024 | By Dr Amber Van Laar (AskBio), Taylor Mixides (Drug Target Review)

Dr Amber Van Laar shares her remarkable journey in STEM. From a childhood fascination with science and medicine to a pivotal role as VP Clinical Development, AskBio. In this interview, she explores the profound impact of her early exposure to neuro-oncology, the challenges faced as a physician-scientist, and the pursuit…

news

Newly discovered role of AF1q in neuroblastoma

28 February 2024 | By Drug Target Review

Researchers have identified that AF1q is highly expressed in neuroblastoma, and could be used to destabilise N-Myc.

news

Enhancing the collateral network for beneficial reperfusion

28 February 2024 | By Drug Target Review

Future interventions for ischaemic stroke patients should enhance collateral function to reduce brain haemorrhage and mortality.

cells Background,Of,Colorful,Oil,Drops,In,Water

article

Gamma delta T cells: a rising star in cancer therapy

28 February 2024 | By Kate Rochlin (IN8bio), William Ho (IN8bio)

Gamma delta (γδ) T cells comprise a distinct and powerful subpopulation of T cells, bridging innate and adaptive immunity, that holds great promise for treating cancer. IN8Bio co-founder and CEO William Ho and COO Kate Rochlin discuss what makes γδ T cells unique, how preclinical research suggests their antitumour activity…

whitepaper

Beyond the lab: artificial intelligence

28 February 2024 | By Drug Target Review

Amidst the transformative era of AI in drug discovery, this report focuses on recent advancements, notably the development of highly accurate drug target models, and how AI is revolutionising precision in identifying drug targets.

news

Key insights into vaccine development for herpesviruses

27 February 2024 | By Drug Target Review

Researchers found that the D48 antibody neutralised HSV-1 virus infection, which could lead to broad-spectrum drug and vaccine development.

news

Uncovering the changes to β-cells at the onset of type 1 diabetes

27 February 2024 | By Drug Target Review

A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.

news

Development of a new recombinant flu vaccine

26 February 2024 | By Drug Target Review

A new vaccine, based on a nanoliposome that promotes proteins to be displayed on its surface, results in potent vaccine efficacy.

Mitochondrial disease Mitochondrial DNA 3D rendering

news

Improved gene editing method for mitochondrial genetic diseases

26 February 2024 | By Drug Target Review

Researchers have developed the world’s first animal model with A-to-G mtDNA edits achieved using engineered TALEDs.

news

New cell culture model reveals neurodegeneration mechanisms

23 February 2024 | By Drug Target Review

Researchers discovered that NPTX2 protein accumulated in cells containing abnormal TDP-43 in FTD and ALS patients.

news

DOP-targeted therapies could exert significant anxiolytic effects

23 February 2024 | By Drug Target Review

Researchers have uncovered the role of the PL-BLA neuronal axis and its potential function in DOP-mediated anxiolytic effects.

news

4PY found to directly trigger vascular inflammation

21 February 2024 | By Drug Target Review

Researchers have discovered a new pathway which seems to be a significant contributor to the development of cardiovascular disease.

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