news
Reducing drug resistance in acute myeloid leukaemia patients
Researchers conducted a proteogenomic characterisation and found that drug exposure changes drug sensitivity.
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news
Organoid drug testing predicts bowel cancer treatment response
A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.
article
The great prostate debate: innovations in prostate cancer screening
While blood tests measuring prostate-specific antigen (PSA) levels have been a primary screening tool, their limitations in specificity have led to challenges such as overdiagnosis and overtreatment. Cleveland Diagnostics is pioneering an alternative approach with the IsoPSA test, focusing on assessing the structure of the PSA protein rather than its…
news
A new machine learning tool identifies drugs to minimise fibrosis
The computer model enables a better understanding of how drugs affect fibroblasts and finds a promising candidate to prevent heart scarring.
news
Advantages of using cfDNA sequencing for early detection of GDM
A deep learning model developed using circulating cell-free DNA outperformed traditional screening methods for gestational diabetes mellitus.
article
How 3D human tissue models are transforming drug discovery
In this Q&A, Keith Murphy, CEO of Organovo, discusses how the shift from animal models to 3D human tissues can transform the preclinical space. Among his many insights, he details the limitations of animal models, how Organovo’s 3D human tissue models facilitate a deeper understanding of genetic expression within specific…
news
Advancing the understanding of placenta accreta spectrum disorder
A new study has identified targets to refine diagnostic tests, track disease progression, and discover more effective therapies.
news
Microbiota composition influences respiratory virus susceptibility
The interactions linking intestinal microbiota with the functionality of basally resident alveolar macrophages and severity of infection are revealed.
article
Advancing neurological therapies with Dr Bruce Leuchter
In the world of neuroscience, where the unmet medical need is vast and diverse, the journey to develop and commercialise treatments for neurological diseases, including rare conditions, is fraught with challenges. In this insightful interview with Dr Bruce Leuchter, President and CEO at Neurvati Neurosciences, with over two decades of…
news
Replacing the PKP2 gene prolongs survival in ARVC patients
The new study suggests that this gene therapy method may combat ARVC in both early and more advanced stages of the condition.
news
Augmenting cancer immunogenicity through MHC class I
A novel technology can reduce tumour sizes significantly and improve treatment efficacy when used with existing immunotherapy.
news
Targeting GBA gene variants for treating Parkinson’s disease
A new project plans to elucidate the relationship between the glucosylceramidase beta gene and Parkinson’s disease.
article
The promise of 3A5C7 mAb in the treatment of morphine tolerance
Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. A monoclonal antibody (mAb) precisely targeting MOR, named as 3A5C7, was developed to treat morphine tolerance by enhancing morphine-induced MOR endocytosis via GRK2/β-arrestin2 pathway. In this Q&A session with Dr Jia-Jia…
podcasts
Navigating the neurological frontier – 2024 and beyond
Listen to this podcast where we step into the new year and explore research insights and projections for the field in 2024 in neuroscience.
news
X-ray irradiation reversed motor deficits after brain injury
Low dose ionising radiation reduced lesion size and reversed motor deficits in traumatic brain injury and ischemic stroke mice.
