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New technique to extract and analyse extracellular vesicles
Cellulose nanofiber sheets enable analysis of EVs, and miRNAs within them, offering potential for cancer treatment and personalised medicine.
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Navigating the challenges of cell therapies
Cell therapies hold great potential for treating complex diseases, yet they face significant limitations and challenges. Current cell therapies have difficulty distinguishing between healthy and cancerous cells, often resulting in adverse effects. Vittoria's innovative Senza5 platform, with its unique CD5-targeting approach, aims to enhance the efficacy, safety, and speed of…
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Limiting diaphragm atrophy in intensive care
Mitochondrial fragmentation mechanism that can cause ventilator-induced diaphragm dysfunction (VIDD) found, and a therapeutic to mitigate it.
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Understanding intracellular processes improves LYTACs therapy
New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.
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DNA epigenetic changes: a key cause of cancer
Analysis of cells shows many regions in DNA are differentially activated or inactivated in a cancer-specific manner.
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Potential new targets for chronic liver disease
Fatty liver disease treatments may become more effective after identification and greater understanding of more drug targets.
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The power of combinations in blood cancers
Haematology research is a cradle of innovation, with many firsts in therapeutic approaches utilising the latest technology for the treatment of blood cancers. Anas Younes, Senior Vice President, Head of Haematology Oncology Research and Development at AstraZeneca, envisions a future where potential cures are within reach for more blood cancers…
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Utilising CAAR T cells to treat antibody-caused brain disease
Researchers have engineered CAAR T cells to destroy harmful antibodies, improving NMDA receptor encephalitis treatment.
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Understanding Z-RNA structure could provide new treatments
A $1.2 million grant has been given to observe how Z-RNA is formed and explore its benefits for various diseases.
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Human organoid research offers insights into gut cell differentiation
How stem cells become enteroendocrine cells using gut organoids could have positive implications for many gastrointestinal diseases.
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Reduced motor symptoms of Parkinson’s disease
In rodent and nonhuman primate animals, circuit-specific gene therapy offers promise for Parkinson’s disease and other brain disorders.
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Alternate origin discovered for brain mosaicism and focal epilepsy
Researchers gain insight into how brain tissue is impacted differently by genetic problems compared to the rest of the body.
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New understanding of early breast cancer development
Mammary organoid cultures show the effects of BRCA2 mutations on breast tissue cells, increasing the likelihood of early, targeted treatment.
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iPSC-derived cells can augment remuscularisation of the heart
Researchers have improved the method of regenerating heart muscle after a heart attack using a combination of iPSC-derived cells.
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Metabolic change in hippocampus indicates Alzheimer’s disease
Using RNA sequencing, scientists find that metabolic increase in the brain is an early indicator of Alzheimer's disease.
