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Issue #1 2023

Addressing the grand challenge of global access to vaccines

19 July 2023 | By Brian Finrow (Lumen Bioscience), Dr Tracy Saveria (Lumen Bioscience), James Roberts (Lumen Bioscience)

Tracy Saveria, James Roberts and Brian Finrow from Lumen Bioscience discuss progress in the aspiration for global vaccine access and how Lumen Bioscience’s inhalation malaria vaccine represents a major step towards it.

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Rare autoantibody diseases: an innovative targeted pathway

7 July 2023 | By Dr Katie Abouzahr

Dr Katie Abouzahr outlines how precision targeting utilising the neonatal fragment crystallisable receptor pathway may provide accessible new treatments for autoantibody diseases.

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Epigenetic editing: the next generation of genetic medicine

7 July 2023 | By Dr Blythe Sather

Dr Blythe Sather at Tune Therapeutics reveals why epigenetic editing offers benefits above and beyond those of gene editing, potentially bridging the gaps to breakthroughs in the clinic.

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Exploring alternatives to animal testing in drug discovery

6 July 2023 | By Ria Kakkad (Drug Target Review)

The use of animal studies in drug development has become a growing ethical concern, particularly given the high failure rate of clinical trials, which can reach up to 90 percent. This article highlights non-animal models that could expedite the drug delivery process from bench to bedside.

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Targeted protein degradation: turning undruggable targets into druggable targets

6 July 2023 | By Izzy Wood (Drug Target Review)

Targeted protein degradation (TPD) is a cutting-edge approach in drug discovery that offers a more precise and efficient way to alter cellular pathways, offering the capability to convert 'undruggable targets' into 'druggable targets.' In this article, Drug Target Review’s Izzy Wood interviewed Astellas’ Masahiko Hayakawa, Head of Targeted Protein Degradation,…

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Under the microscope: The remit of expertise putting nanomaterials to work

12 April 2023 | By nanoComposix, Tom Darlington

Tom Darlington, Senior Director at nanoComposix, discusses scaling up manufacturing of nanomaterials for regulated applications and the rewards of working on biomedical projects.

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Under the microscope: Sustaining momentum in iPSC-derived allogeneic cell therapies

12 April 2023 | By Andy Holt, Cellistic, Dr Stefan Braam

Drug Target Review connects with Dr Stefan Braam, co-founder and CTO of Cellistic, and Andy Holt, CCO of Cellistic, for a rundown on today’s landscape for allogeneic cell therapies.

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SARS-CoV-2 spike protein dihedral angle oscillations reveal favoured rotation frequencies

30 March 2023 | By Dr Oscar Bastidas, Dr Zoran Sevarac

As new variants of the SARS-CoV-2 virus emerge, leading scientists Dr Oscar Bastidas and Dr Zoran Sevarac explore how their latest research identified a structured frequency domain profile in data with no discernible pattern. Their article also emphasises that it remains imperative to continue learning about this pathogen’s molecular machinery…

Tools for PCR amplification of DNA: 96-well plate and automatic pipette

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Assay performance and the Z’-factor in HTS

30 March 2023 | By Dr Matthew Lloyd (University of Bath)

Matthew Lloyd from the University of Bath reveals the importance of the Z-factor and Z’-factor in high-throughput screening, and how they can be used to determine assay performance, perform quality control on the screen, and identify active compounds.

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An approach to mRNA vaccine development in the wake of COVID-19

30 March 2023 | By Brad Sorenson (Providence Therapeutics)

Brad Sorenson, CEO of Providence Therapeutics, shares the future developments and exciting potential of mRNA therapies, including improved efficacy and wider access to vaccines, and future promise for cancer treatment.

Pipette with transparent drop over glass test tubes

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De-risking drugs in multiplex assays before progressing to clinical trials

30 March 2023 | By Dr Sheraz Gul (Fraunhofer Institute)

Sheraz Gul, Head of Assay Development and Drug Repurposing at the Fraunhofer Institute, discusses the importance of performing comprehensive multiplex spatial and temporal profiling of drugs in pre-clinical research to decrease the risk of potentially undesirable events in later clinical studies.

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Product hub: Why automation is outpacing traditional methods for single-cell cloning

30 March 2023 | By Sartorius

Learn more about the CellCelector platform and its unique nanowell plate technology, which is key to the high cell integrity and outgrowth rates after picking.

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Application note: Revolutionising drug formulations with polysorbate detection

30 March 2023 | By Halo Labs

Transform your drug manufacturing process with the latest breakthroughs in technology. Effortlessly identify and differentiate degradation components of PS20 in protein-containing samples.

Robot conducting experiments in a laboratory. Robot working in a laboratory with a test tube. Robot manipulating with test tube in a laboratory. Vector flat design illustration. Horizontal layout.

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The future of lab automation: streamlining drug research

29 March 2023 | By Izzy Wood (Drug Target Review), Ria Kakkad (Drug Target Review)

In this article, Drug Target Review's Ria Kakkad and Izzy Wood explore the results of the latest research on lab automation techniques and technologies designed to accelerate drug discovery.

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Drug Target Review Assays ebook 2023

29 March 2023 | By Drug Target Review

Download your FREE ebook on assays, featuring articles from experts who write about developments in screening and the importance of performing comprehensive multiplex spatial and temporal profiling of drugs in pre-clinical research.

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Issue #1 2023