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Issue #2 2017

Inflammatory biomarkers as a herbal anti-arthritic drug discovery tool

11 July 2017 | By Amita Verma (Shalom Institute of Health and Allied Sciences), Firoz Anwar (King Abdulaziz University), Imran Kazmi (Glocal School of Pharmacy), Mahfoozur Rahman (Sam Higginbottom Institute of Agriculture Technology & Sciences), Sarwar Beg (Jubilant Generics Limited), Vikas Kumar (Sam Higginbottom Institute of Agriculture Technology & Sciences)

Rheumatoid arthritis (RA) is joint-related, immune-based inflammatory disarray that affects almost 1% of the world’s population. The most evidenced pathogenesis is T-cell activation, which leads to clusters of differentiation (CD) in the T-cells and concurrently increases various inflammatory biomarkers.

Phenotypic and target-based screening: complementary or competing?

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Phenotypic and target-based screening: complementary or competing?

11 July 2017 | By Sheraz Gul (Fraunhofer-IME SP)

The screening of drug targets against compound libraries is now a mature and validated approach to identifying the chemical starting points of drugs...

article

Using clinical drug resistance to kill cancer cells

11 July 2017 | By Howard Fearnhead - NUI Galway, Sheraz Gul (Fraunhofer-IME SP)

Drug resistance is a significant therapeutic problem, from infectious diseases to cancer. Given a large enough population of genetically varying target cells, the emergence of drug resistance is not surprising and is even unavoidable...

article

Development by design methodology: the key to successful manufacturing of patient-specific cell therapies

11 July 2017 | By Brian Hampson, David Smith

Recognised as the next wave of medicine, cell therapies have made significant strides over the last several years. But such advancements can present unique challenges, especially as more products move out of the clinic and toward commercialisation. And unlike typical pharmaceuticals, cell therapies rely heavily on the manufacturing process to…

David F Fischer, PhD, Executive Director Biology at Charles River

article

David F Fischer on target screening

10 July 2017 | By Drug Target Review

Drug Target Review editor Steve Bremer asks David F Fischer for his views on target discovery and validation in drug discovery. David F Fischer, PhD, is Executive Director Biology at Charles River...

article

Using venoms to uncover new targets in drug discovery

7 July 2017 | By Steve Trim (Venomtech Ltd)

A range of drugs used in modern medicine are derived from animal venoms, and Steve Trim from Venomtech discusses how natural selection has made venoms particularly useful tools for uncovering new targets in drug discovery...

article

New drug targets identified to defend against chlamydia infections using CRISPR and stem cells

7 July 2017 | By Amy Yeung (Wellcome Trust Sanger Institute)

Human induced pluripotent stem cell derived macrophages (iPSDMs) provide a cell-based model system to study chlamydia infection in the laboratory. Amy Yeung from Wellcome Trust Sanger Institute explains how she used this model in combination with CRISPR-Cas 9 technology to explore the potential of the two genes, IRF5 and IL10RA,…

Intracellular target validation in cellular systems … using peptides!

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Intracellular target validation in cellular systems … using peptides!

7 July 2017 | By Paul Grant (Venomtech)

Paul Grant from Venomtech suggests that because animal venoms contain proteins and peptides that disrupt cell membrane integrity, they offer a new approach to drug discovery...

Targets in-depth focus digital issue #2 2017

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Targets In-Depth Focus 2017

5 June 2017 | By Drug Target Review

Included in this Targets In-Depth Focus: Intracellular target validation in cellular systems; New drug targets identified to defend against chlamydia infections using CRISPR and stem cells; Novel solutions for tough targets with real bite...

Stem Cells in-depth focus digital issue #2 2017

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Stem Cells In-Depth Focus 2017

5 June 2017 | By Drug Target Review

Included in this Stem Cells In-Depth Focus: Translating discoveries into therapies; The key to successful manufacturing of patient-specific cell therapies; Interview with Alessandro Prigione and James Adjaye...

Screening in-depth focus digital issue #2 2017

article

Screening In-Depth Focus 2017

5 June 2017 | By Drug Target Review

Included in this Screening In-Depth Focus: Phenotypic and target-based screening; Killing cancer cells using clinical drug resistance; Inflammatory biomarkers as a herbal anti-arthritic drug discovery tool...

article

Insights from discovery through clinical efficacy to support a new class of therapeutics in Alzheimer’s disease

2 June 2017 | By Aidan Power, John A Hey, Martin Tolar, Petr Kocis, Susan Abushakra

Research into innovative small molecule therapeutics with disease modifying potential in Alzheimer’s disease (AD) has been conducted at Alzheon since 2013.

article

Using native mass spectrometry to inform drug discovery

2 June 2017 | By Carol V Robinson, Hsin-Yung Yen, Idlir Liko, Jonathan ST Hopper, Timothy Allison

Mass spectrometry (MS) performed under native-like conditions (nMS) is a promising approach for studying protein-drug interactions, and has already informed treatments of some of the most intractable diseases including cancer, diabetes and Alzheimer’s.

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Review: Biomarkers towards personalised therapy in cancer

2 June 2017 | By Katheryn Begg (King's College London), Mahvash Tavassoli (King's College London)

Since the sequence of the human genome was published some 20 years ago, omics strategies have enabled the generation of detailed molecular signatures of cancers and their subtypes.

article

Drug Target Review – Issue #2 2017

2 June 2017 | By Drug Target Review

Included in this issue: Technology convergence improves testing; Screening; Stem Cells; Targets; Mass Spectrometry; and Therapeutics in Alzheimer's disease...

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Issue #2 2017