New analysis of brain activity offers insight into epileptic seizures

Recent advances have led to a conceptualisation of epilepsy as a “network disease” exhibiting connections within the brain. This large-scale epileptic network comprises various areas of the brain involved in normal brain activity during both seizure-free intervals and those involved in so-called pathophysiological activities such as seizures.

Complex brain network

Little is known, however, about which specific areas of the brain contribute to a patient’s epileptic network or the roles these different areas play. One way to get closer to the complex wiring of the human brain is by merging concepts from a timed-based synchronisation theory and space-based network theory to construct functional brain networks.

Until now, the “seizure-generating area” of the brain in which the earliest signs of seizure activity can be observed was considered the most important of these regions. This finding was based on very limited data and it was unclear whether its importance changes with time.

Temporal and spatial variability

With this new analytical approach, Professor Klaus Lehnertz, head of the Neurophysics Group in the Department of Epileptology at the University of Bonn, and his group explored the temporal and spatial variability of the importance of the brain’s different regions.

By associating network nodes with individually sampled brain regions, Lehnertz’s group can define a link between a pair of nodes by assessing the degree of synchrony between neuronal signals from all pairs of nodes; the higher the degree, the stronger the link.

Studying individual brains

“Applying these analysis concepts to multichannel long-term EEG recordings from 17 epilepsy patients with high temporal resolution allowed us to derive a sequence of functional brain networks spanning several days in duration,” said Christian Geier, a doctoral student working with Lehnertz.

The group’s work is particularly significant because they showed for the first time how the importance of individual nodes within functional brain networks fluctuates on timescales spanning tens of seconds up to days. They further showed that these fluctuations can be largely attributed to the normal, daily rhythms of a patient, yet only minimally attributed to phenomena directly related to the disease.

Hierarchy of regions

Perhaps their most intriguing finding is that in general, according to Geier, there isn’t a constant importance hierarchy between brain regions.

The understandings gained from this research are part of the necessary foundation for developing treatments related to the causes and symptoms of epilepsy.

 Controlling seizures

“When different brain regions assume the highest importance within a functional brain network is the key to improving both prediction and control of epileptic seizures,” Lehnertz said.

“In the long run, this improved understanding may enable the development of better treatment options for patients suffering from epilepsy. And understanding the importance of the nodes and links of functional brain networks may also be relevant for other neurological diseases.”