Farnesol shows potential to prevent and treat Parkinson’s disease
Researchers have added to evidence that farnesol prevents and reverses brain damage linked to Parkinson’s disease in mouse models.
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AKT degrader may become a new, effective treatment for many cancers
Researchers have discovered a therapeutic agent that is effective in vitro at disrupting a biological pathway that helps cancer survive.
Genetic treatment reverses age-related memory loss in mice
Scientists have shown that manipulating the perineuronal nets (PNNs) in the brains of mice led to the reversal of age-related memory loss.
“Untreatable” cases of cystic fibrosis may be undermined by new therapy
An experimental drug suggests that therapy for currently untreatable cases of cystic fibrosis is “clearly achievable”.
Exosome formulation developed for choroidal neovascularisation therapy
An exosome formulation has been created to deliver vascular endothelial-growth factor (VEGF) antibodies for choroidal neovascularisation therapy in models.
Inhibiting PIP4K enzymes could help immune system fight cancer
Researchers identified a potential therapeutic involving the inhibition of PIP4K enzymes which could enable the immune system to destroy tumour cells.
Llama nanobodies could serve as new treatment for HCMV
Scientists have developed a “llama nanobody” that is capable of chasing out human cytomegalovirus (HCMV) so it is detected by the immune system.
New “atlas” charts how antibodies attack COVID-19 Spike variants
A new “atlas” has been created in the US that charts how 152 different antibodies attack the SARS-CoV-2 Spike protein.
Personalised organoid models may improve immunotherapy treatment
Researchers have used patient-specific tumour organoid models to improve immunotherapy treatments for appendiceal cancer.
Algorithm helps find best drug targets for all COVID-19 variants
A new computer algorithm has identified highly conserved sequences in viral proteins that could make the best drug targets for COVID-19.
Bacterial metabolites could increase tumour therapy efficiency
Bacterial metabolites showed an increase in the cytotoxic activity in immune cells that could potentially influence efficiency of tumour therapies.
Researchers develop toxicity test for placenta and embryos
A Swiss team have created a laboratory test that incorporates the placenta into embryotoxicity assessments without damaging foetuses.
Novel group of small molecules show promise against SARS-CoV-2
Researchers in Germany have identified 69 small molecules as binding partners for genomic RNA of SARS-CoV-2, possibly leading to new drugs.
Treg cells could be answer to multiple sclerosis treatments, say scientists
New research has shown that the protein Piezo 1 prevented Treg cells from controlling the effects of inflammation in a multiple sclerosis mouse model.
Metabolite could defend against harmful intestinal bacteria, study shows
Acetate was found to be involved in regulating complex microbes and could help trigger an immune response against harmful bacteria in mice.
