Team develops cerebral organoid system to screen for CJD drugs
Researchers have developed their previously created brain organoid to test for potential drugs against Creutzfeldt-Jakob disease (CJD).
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New software could enable the design of DNA robots for drug delivery
Researchers have developed software that can design complex DNA nanodevices which could be used to deliver medicine while in the body.
Algorithm created to analyse large single-cell sequencing datasets
An algorithm which continuously processes new data has been developed to allow researchers to access and analyse single-cell sequencing information.
Novel COVID-19 vaccine could offer broad protection from coronaviruses
A new COVID-19 vaccine could provide protection from severe infection from a range of coronaviruses, studies in pigs have shown.
Scientists develop new CRISPR-based tool to control epigenome
Researchers have used CRISPR to create a new technology that can switch off almost any gene in cells, called CRISPRoff.
MK-4482 antiviral effective against SARS-CoV-2 in hamster study
The drug MK-4482 decreased viral levels in the lungs of hamsters treated for SARS-CoV-2 infection, researchers have shown.
Assay developed to detect cathepsin B in blood samples
Scientists have created an assay to detect the protein cathepsin B in blood, a biomarker for a range of diseases.
Researchers increase frame rate of high-speed atomic force microscopy
By increasing the frame rate of atomic force microscopy to 30 frames per second, scientists found the technique was faster and less invasive.
Brain organoids reveal mechanisms of virus-induced microcephaly
Researchers have shown how different viruses such as HSV-1 and Zika can lead to microcephaly using brain organoids.
Machine learning method to design better antibody drugs developed
Researchers have developed an artificial intelligence to identify the best potential antibody drug from groups of up to a few thousand.
Scientists generate human-monkey chimeric embryos
An international collaboration has led to the development of monkey embryos able to grow with injected human stem cells.
Reduced levels of H2S in rat brains protects against dementia
A study has shown that treatments to reduce levels of hydrogen sulphide (H2S) in the brain may help to prevent dementia.
First patient-derived organoid model for cervical cancer developed
Novel organoid models of cervical cancer and a healthy human cervix have been developed to study the condition and its progression.
Self-assembling nanofibres could prevent damage from inflammation
A team has demonstrated in mouse models that a self-assembling nanofibre material could limit the damage caused by cytokines in inflammatory diseases.
Fragment screening used to identify potential SARS-CoV-2 antivirals
Researchers have used fragment screening alongside computational docking to reveal 20 hit antiviral compounds against SARS-CoV-2.