Study identifies potential drug target for treating COVID-19
Researchers have shown that the PLpro coronavirus enzyme presents a possible target in the fight against COVID-19.
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Machine learning calculates affinities of drug candidates and targets
A novel machine learning method called DeepBAR could accelerate drug discovery and protein engineering, researchers say.
Researchers gain insight into metabolic pathways hijacked by SARS-CoV-2
SARS-CoV-2 diverts building blocks from glucose production to the assembly of purine bases, researchers have found.
Nanolitre‐scale cell assays developed with droplet microarray-mass spec
A team has developed nanolitre cell assays on droplet microarrays to enable pharmacodynamic monitoring in live cells.
Novel deep learning tool developed to analyse microscopy images
An artificial intelligence platform has been created to enable tens of thousands of microscopy images to be generated in an hour.
Researchers reveal how key enzyme APT2 works in cells
Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.
First lab-grown mini-thyroids produced from patients’ own tissue
Thyroid mini-organs have been generated in the lab by researchers, which are able to self-renew and differentiate into functional tissue.
RNA protein shown to protect telomeres and support cancer proliferation
A team has revealed a function of ADAR1, responsible for RNA editing, discovering an isoform used for cancer growth, making it a drug target.
Antibodies from COVID-19 vaccines less effective against SARS-CoV-2 variants
Researchers have shown antibodies induced by the Pfizer and Moderna vaccines are less effective at neutralising certain SARS-CoV-2 variants.
Researchers reveal 3D structure responsible for gene expression
Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.
New tool designed to add or remove sugar from proteins shows success
Researchers have developed a new tool that can add or remove sugar from proteins, which could be used to treat currently "undruggable" targets.
Team improves non-invasive visualisation of photoreceptors in eye
A new imaging technique for photoreceptors has been developed by selectively blocking light used to observe the eye.
Nano-micelles used in CRISPR genome editing of mouse brains
Researchers have reported that nano-micelles can be used to efficiently deliver CRISPR-Cas9 to edit genes in the brains of mice.
Mosquito protein could hold key to therapeutics against flaviviruses
A study has shown the mosquito protein AEG12 inhibits flaviviruses, the family of viruses that cause yellow fever, dengue and Zika.
New liver-on-a-chip model successfully mimics NAFLD
A liver-on-a-chip model has been developed to more fully represent the natural progression of NAFLD than previous models.