Researchers study iPSCs to uncover genetic causes of disease
Sequencing and transcriptome data on iPSCs has been used to identify correlations between genetic variants and expression patterns.
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Researchers identify key enzymes to synthesise natural products
A team has discovered how enzymes control the formation of bioactive rubromycin-polyketides, which could be used to bioengineer new compounds.
Structure of protein that triggers neurodegeneration isolated and analysed
Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.
Reversible male contraceptive shows promise in pre-clinical studies
Researchers have discovered the the compound triptonide is safe, effective and reversible as a male contraceptive in animal models.
Researchers use viruses as vectors to deliver cancer vaccines
A team has used two viruses to administer specific tumour components in mice with cancer to stimulate their immune system.
Compounds that inhibit main protease of SARS-CoV-2 discovered
Using high-throughput screening techniques, researchers have identified two families of active substances that block SARS-CoV-2 replication.
Researchers modifiy E. coli to produce chondroitin sulphate
A team has created a biosynthetic pathway for E. coli that allows the bacteria to produce a common arthritis drug.
Nanoparticle COVID-19 vaccine shows promise in pre-clinical trials
A new nanoparticle-based vaccine has demonstrated success in ferret models of COVID-19, inducing strong neutralising antibodies against SARS-CoV-2.
New drug shows potential as prophylactic for Alzheimer’s disease
In pre-clinical studies, a novel treatment decreased plaque formation, meaning it could be used to prevent Alzheimer's disease.
In silico screening of existing drugs reveals three candidates against SARS-CoV-2
A novel in silico approach applied to drug screening has revealed three potential candidates that may interact with multiple proteins of SARS‐CoV‐2.
Balanced T-cell response key to asymptomatic COVID-19, study suggests
A new study has suggested that asymptomatic individuals with COVID-19 mount an efficient T-cell response that protects the host.
Atomic force microscopy used to study endonuclease digestion of DNA nanostructures
A team of researchers have used microscopy techniques to monitor DNA degradation and anticancer drug release from nanostructures.
Screening by compound activity could accelerate drug discovery
Researchers have developed a new screening technique called biological activity-based modelling to identify drug candidates.
Vaccine strategy developed to fight urinary tract infections
Researchers have shown that administering a urinary tract infection vaccine directly to the bladders of mice helped them to effectively fight bacteria.
SARS-CoV-2 model shows Spike protein co-operation
A new coarse-grained model of the complete SARS-CoV-2 virion has revealed potential new ways to combat the coronavirus.