High-throughput screening assay for macrocyclic peptides developed
A high-throughput screening assay for macrocyclic peptides with affinity to ubiquitin has been created by researchers.
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New technology enables predictive design of engineered human cells
Researchers have developed a computer modelling programme that can produce genetic circuits for cellular engineering.
Analysis conducted on glycan structure from sheep prion strains
Using liquid chromatography/mass spectrometry, researchers have revealed no major differences in glycan structures in two prion strains.
Researchers find MAPK4 enzyme presents target for prostate cancer
Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
Study shows that FOXO3 gene protects brain stem cells
A version of the FOXO3 gene can protect brain stem cells from stress during ageing, according to a new study.
UK Government to fund four studies investigating long COVID
The UK Government will give £18.5 million in funding to four studies researching the causes and potential treatments of long COVID.
Team modifies therapeutic molecule to improve stroke treatment
Researchers have shown that adding a polymer to glutamate-oxaloacetate transaminase means the molecule can treat stroke for up to six days in rats.
Bile duct organoids could be used as cell therapy for regenerative medicine
For the first time, scientists have grown bile duct organoids that could repair damaged ducts and livers as a new cell therapy.
UK industry leaders call for reform to outdated R&D tax rules
A report has been backed by eight industry leaders who say that updating R&D tax credit systems in the UK would release £4 billon of growth every year.
NAD depletion by IFN sensitises pancreatic cancer to NAMPT inhibition, study shows
High IFN signalling in pancreatic tumours are sensitive to NAMPT inhibitors which block a pathway in NAD synthesis, presenting a drug target.
D614G Spike mutation makes SARS-CoV-2 up to eight times more infectious
A study has shown the D614G mutation in the Spike protein of SARS-CoV-2 makes the coronavirus more transmissible than the original virus from China.
LEAP proton therapy could target cancer cells that resist treatment
A proton therapy that targets cancer cells which are resistant to treatment has shown success, sparing surrounding healthy cells.
Engineered peptide protects ferrets against SARS-CoV-2 transmission, study shows
A peptide administered to ferrets protected them from SARS-CoV-2 viral transmission when housed with infected ferrets.
New nanotherapy could potential treat Crohn’s disease in children
A novel nanotherapy can decrease intestinal inflammation and shrink lesions in rodent models of Crohn's disease, a study has shown.
New drug combination could combat Diffuse Intrinsic Pontine Glioma
The drug combination of difluoromethylornithine and AMXT 1501 has shown success against Diffuse Intrinsic Pontine Glioma in animal models.