Hereditary Alzheimer’s disease can be transferred via transplants
Transplant recipients of hematopoietic stem cells with a hereditary version of AD developed the disease at an accelerated rate.
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New trivalent vaccine for clade 1 sarbecoviruses
The vaccine provided complete protection with no detectable virus in the lungs and could be a routine part of people’s medical treatment.
Uncovering the functional role of sRNAs in bacterial adaptation
Researchers find how antibiotic treatments influence the microbiota, providing new strategies for preventing antibiotic-induced damage.
MUTYH variants implicated in a broader range of cancers
The discovery that one missing copy of MUTYH could increase the risk of cancers may lead to therapeutics against solid tumours.
Blastoids enable greater understanding of human gastrulation
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.
New AI model could help to overcome antibiotic resistance
Six molecules that had potent antibacterial effect against one of the world’s most dangerous antibiotic-resistant bacteria were generated.
The genetic mutation causing the development of psoriatic arthritis
Mutation in two copies of the IKBKB gene leads to abnormal function of regulatory T cells, causing psoriatic arthritis.
FGF2 and SOX17 enable more efficient stem cell differentiation
The discovery of two proteins that effectively mature hiPSCs into endothelial cells may have a range of research and clinical benefits.
Study concludes that most aspects of aging relate to gene length
New findings about how long genes become less active with age could impact treatments for neurodegeneration, among other conditions.
The first core regulatory circuit identified for ALCL
New understanding of the CRC and its interaction with STAT3 could lead to novel therapeutics and combination strategies.
Discovery of genetic variants that influence Alzheimer’s disease
Whole genome sequencing identified 17 significant variants associated with AD risk in five genomic regions.
New strategies to overcome CAR T-cell resistance in AML cells
Pharmacological concomitant therapies or further genetic improvement of CAR T-cells can increase their effectiveness against TP53-mutant AML cells.
The mechanism of PARP inhibitor action is identified
New findings will enable the development of safer PARP inhibitors that inhibit PARP’s enzymatic activity without trapping it on DNA.
Exact bacterial lineage associated with colorectal cancer pinpointed
Researchers have discovered two distinct lineages of Fusobacterium nucleatum, which has great implications for colorectal cancer screening and therapeutics.
Determining the cellular architecture of multiple sclerosis lesions
Using in situ sequencing, a collaborative research group analysed 260 genes and discovered new sub-structures in MS lesions.