Next-generation diabetes prodrugs identified using novel screening platform
Researchers engineered the Disque Platform, a high-fidelity culture system, to enable them to screen drugs able to promote β cell proliferation.
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Single interaction could explain the disparity in COVID-19 effects
According to researchers, an interaction between host microRNA and SARS-CoV-2 could be responsible for the range of disease severities.
Novel class of targeted cancer therapies could treat myeloid leukaemias
Cancer researchers have created a new class of drugs to selectively target and destroy myeloid leukaemia cells with TET gene mutations.
New drug may boost vaccine responses in older adults
Researchers have found that spermidine can ramp up autophagy and boost T-cell function, potentially increasing the protective effects of vaccines in older adults.
Opaganib shows promise in preventing ARDS-induced thrombosis
Opaganib reduced blood clot length and weight in a pre-clinical model of Acute Respiratory Distress Syndrome (ARDS).
Researchers develop drug discovery tool for RNA
Scientists have created a drug discovery platform that enables the discovery and optimisation of RNA-targeting compounds.
One-step method developed to generate mice for vaccine research
Using CRISPR-Cas9, scientists have developed a new method for generating mouse lines for vaccine research in just a few weeks.
Biomarkers for predicting COVID-19 disease severity
Scientists have created a prognostic classification model which uses biomarkers to help predict an individual’s risk of developing severe COVID-19 symptoms.
New SARS-CoV-2 strain identified in South East England
UK Health Secretary Matt Hancock has said there is a mutated form of SARS-CoV-2 that may be causing a rise in infections in South East England.
Identification of novel biosynthetic pathways in lichens could lead to new therapeutics
Scientists have identified a new family of biosynthetic genes in lichens with unknown functions, which could produce new molecules for the pharmaceutical industry.
Genome-wide association study reveals targets for COVID-19 treatments
The study found five key genetic differences when they compared sequences from severe COVID-19 patients to healthy individuals.
Researchers develop computer algorithm to identify cancer cell lines
Scientists have trained a computer algorithm to identify differences in cancer cell lines based on microscopic images, preventing the misclassification of cells.
Protein identified as potential target for leishmaniasis vaccines
New research has demonstrated in mouse models that the SHP-1 protein limits the capacity of dendritic cells, making it a target for a leishmaniasis vaccine.
Computational mass spectrometry method accelerates speed of data acquisition
A new subspace mass spectrometry imaging method has enabled researchers to provide data sets exponentially faster.
Haematoxylin could be a promising therapy for bone marrow cancers
Study shows that haematoxylin can selectively kill cancers with a mutated form of the calreticulin gene (CALR), common in a group of bone marrow cancers called myeloproliferative neoplasms (MPNs).